naa a22 4500 510813674 CHVBK 20180411083454.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12328-013-0416-8 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0416-8 Mixed acinar-endocrine carcinoma of the pancreas treated with S-1 [Elektronische Daten] [Yusuke Kanemasa, Terumi Kamisawa, Taku Tabata, Sawako Kuruma, Susumu Iwasaki, Kazuro Chiba, Go Kuwata, Takashi Fujiwara, Hideto Egashira, Koichi Koizumi, Junko Fujiwara, Takeo Arakawa, Kumiko Momma, Hirofumi Rokutan, Shinichiro Horiguchi, Tsunekazu Hishima] The case of a 63-year-old male with a large mass in the pancreatic tail and multiple liver metastases, diagnosed as acinar cell carcinoma of the pancreas with a few scattered endocrine cells by liver biopsy is presented. The S-1 chemotherapy was effective, and partial response was obtained with decreased levels of serum CA19.9 and NSE. Ten months after starting chemotherapy, the tumor began to grow accompanied by marked elevation of serum NSE levels (266ng/ml). The patient died of liver failure due to multiple liver metastasis 18months after the initiation of the S-1 chemotherapy. Histological findings at autopsy were acinar cell carcinoma with an endocrine component of more than 30%; the final diagnosis was mixed acinar-endocrine carcinoma of the pancreas. This pathological change and clinical course may imply that S-1 was effective against the acinar component but less effective against the neuroendocrine component caused by tumor differentiation. Springer Japan, 2013 Mixed acinar-endocrine carcinoma nationallicence Acinar cell carcinoma nationallicence Pancreas nationallicence S-1 nationallicence Kanemasa Yusuke Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Kamisawa Terumi Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Tabata Taku Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Kuruma Sawako Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Iwasaki Susumu Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Chiba Kazuro Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Kuwata Go Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Fujiwara Takashi Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Egashira Hideto Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Koizumi Koichi Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Fujiwara Junko Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Arakawa Takeo Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Momma Kumiko Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut Rokutan Hirofumi Departments of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan aut Horiguchi Shinichiro Departments of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan aut Hishima Tsunekazu Departments of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/6(2013-12-01), 459-464 1865-7257 6:6<459 2013 6 12328 https://doi.org/10.1007/s12328-013-0416-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0416-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kanemasa Yusuke Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kamisawa Terumi Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Tabata Taku Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kuruma Sawako Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Iwasaki Susumu Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Chiba Kazuro Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kuwata Go Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujiwara Takashi Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Egashira Hideto Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Koizumi Koichi Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujiwara Junko Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Arakawa Takeo Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Momma Kumiko Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113-8677, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Rokutan Hirofumi Departments of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Horiguchi Shinichiro Departments of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Hishima Tsunekazu Departments of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/6(2013-12-01), 459-464 1865-7257 6:6<459 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer