naa a22 4500 510813763 CHVBK 20180411083455.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12328-013-0420-z doi (NATIONALLICENCE)springer-10.1007/s12328-013-0420-z Elevated paraneoplastic hypercholesterolemia in a case of hepatoid adenocarcinoma of the stomach with liver metastasis [Elektronische Daten] [Tetsuro Sohda, Hiroyuki Kusuhara, Yoshiki Egashira, Keisuke Egashira, Koichi Eguchi, Kunihiko Aoyagi, Shotaro Sakisaka] A 67-year-old man was admitted to our hospital because of a large liver tumor revealed by ultrasonography. Laboratory data showed increased serum levels of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP), which are tumor markers for hepatocellular carcinoma. In addition, the serum cholesterol level was extremely high. Endoscopic examination revealed advanced gastric cancer. Histological findings of the stomach and liver tumor showed they were both hepatoid adenocarcinomas and were both positive for antibodies against AFP as well as DCP, suggesting that the tumors were gastric cancer with liver metastasis. Moreover, 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a key enzyme for regulation of cholesterol synthesis, was upregulated in the tumor tissues. Accordingly, we diagnosed this patient with AFP- and DCP-producing gastric cancer accompanied by paraneoplastic hypercholesterolemia. Paraneoplastic hypercholesterolemia is sometimes seen in hepatocellular carcinoma, but never in gastric cancer. This case is interesting because of the feature of hepatoid adenocarcinoma. Springer Japan, 2013 Alpha-fetoprotein (AFP) nationallicence Des-gamma-carboxy prothrombin (DCP) nationallicence Hepatoid adenocarcinoma nationallicence Hypercholesterolemia nationallicence Paraneoplastic syndrome nationallicence 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase nationallicence Sohda Tetsuro Department of Gastroenterology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jonan-ku, Fukuoka, Japan aut Kusuhara Hiroyuki Sakura Hospital, 4-16-15 Katae, 814-0142, Jonan-ku, Fukuoka, Japan aut Egashira Yoshiki Sakura Hospital, 4-16-15 Katae, 814-0142, Jonan-ku, Fukuoka, Japan aut Egashira Keisuke Sakura Hospital, 4-16-15 Katae, 814-0142, Jonan-ku, Fukuoka, Japan aut Eguchi Koichi Department of Gastroenterology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jonan-ku, Fukuoka, Japan aut Aoyagi Kunihiko Department of Gastroenterology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jonan-ku, Fukuoka, Japan aut Sakisaka Shotaro Department of Gastroenterology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jonan-ku, Fukuoka, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/6(2013-12-01), 424-428 1865-7257 6:6<424 2013 6 12328 https://doi.org/10.1007/s12328-013-0420-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0420-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sohda Tetsuro Department of Gastroenterology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jonan-ku, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kusuhara Hiroyuki Sakura Hospital, 4-16-15 Katae, 814-0142, Jonan-ku, Fukuoka, Japan aut NATIONALLICENCE 700 1- Egashira Yoshiki Sakura Hospital, 4-16-15 Katae, 814-0142, Jonan-ku, Fukuoka, Japan aut NATIONALLICENCE 700 1- Egashira Keisuke Sakura Hospital, 4-16-15 Katae, 814-0142, Jonan-ku, Fukuoka, Japan aut NATIONALLICENCE 700 1- Eguchi Koichi Department of Gastroenterology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jonan-ku, Fukuoka, Japan aut NATIONALLICENCE 700 1- Aoyagi Kunihiko Department of Gastroenterology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jonan-ku, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sakisaka Shotaro Department of Gastroenterology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jonan-ku, Fukuoka, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/6(2013-12-01), 424-428 1865-7257 6:6<424 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer