naa a22 4500 51081378X CHVBK 20180411083455.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12328-013-0436-4 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0436-4 Innate immunity and inflammatory bowel disease: a review of clinical evidence and future application [Elektronische Daten] [Kyoko Katakura, Hiroshi Watanabe, Hiromasa Ohira] Abstract : Inflammatory bowel disease (IBD) is a chronic inflammatory disorder caused by dysregulated immune responses in a genetically predisposed individual. Recent accumulating data, including genome-wide association studies, have identified >100 distinct genetic loci that confer susceptibility. We highlight how the dysregulation of host−microbial interaction leads to intestinal inflammation, particularly with respect to the overlap of common genetic and pathophysiological mechanisms of IBD. Springer Japan, 2013 IBD nationallicence Innate immunity nationallicence Katakura Kyoko Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Watanabe Hiroshi Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Ohira Hiromasa Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/6(2013-12-01), 415-419 1865-7257 6:6<415 2013 6 12328 https://doi.org/10.1007/s12328-013-0436-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0436-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Katakura Kyoko Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Watanabe Hiroshi Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Ohira Hiromasa Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/6(2013-12-01), 415-419 1865-7257 6:6<415 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer