naa a22 4500 510813801 CHVBK 20180411083455.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12328-013-0377-y doi (NATIONALLICENCE)springer-10.1007/s12328-013-0377-y Barrett's esophageal carcinoma consisting of undifferentiated carcinoma and differentiated adenocarcinoma: report of case [Elektronische Daten] [Otohiro Katsube, Shin Saito, Yoshinori Hosoya, Toshihide Komatsubara, Takashi Ui, Kentaro Kurashina, Hidenori Haruta, Toru Zuiki, Takehiko Yamaguchi, Naohiro Sata, Yoshikazu Yasuda] We report on a 53-year-old male with esophageal cancer. He had no evidence of distant metastasis, and received a subtotal esophagectomy. Histopathologically, the tumors were contiguous with Barrett's epithelium. Undifferentiated carcinoma components existed independently of differentiated adenocarcinoma components. Undifferentiated carcinoma was present proximal to the esophagogastric junction. Both tumors had invaded the submucosa and were associated with a prominent lymphoid stroma. Metastasis from undifferentiated carcinoma was found in the paraesophageal lymph nodes. Immunohistochemically, both components were negative for 34bE12 and positive for CAM5.2 and showed nearly identical staining patterns for p53, indicating that the tumors were derived from Barrett's epithelium. Because the undifferentiated carcinoma did not express CK20 or carcinoembryonic antigen, the properties of adenocarcinoma had apparently been lost during the process of tumor cell progression. This is the first report of undifferentiated carcinoma associated with Barrett's esophagus with adenocarcinoma. Springer Japan, 2013 Barrett's esophagus nationallicence Undifferentiated carcinoma nationallicence Lymphoid stroma nationallicence Katsube Otohiro Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Saito Shin Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Hosoya Yoshinori Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Komatsubara Toshihide Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Ui Takashi Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Kurashina Kentaro Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Haruta Hidenori Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Zuiki Toru Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Yamaguchi Takehiko Department of Pathology, Jichi Medical University, Tochigi, Japan aut Sata Naohiro Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Yasuda Yoshikazu Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/3(2013-06-01), 207-210 1865-7257 6:3<207 2013 6 12328 https://doi.org/10.1007/s12328-013-0377-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0377-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Katsube Otohiro Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Saito Shin Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Hosoya Yoshinori Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Komatsubara Toshihide Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Ui Takashi Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Kurashina Kentaro Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Haruta Hidenori Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Zuiki Toru Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Yamaguchi Takehiko Department of Pathology, Jichi Medical University, Tochigi, Japan aut NATIONALLICENCE 700 1- Sata Naohiro Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Yasuda Yoshikazu Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/3(2013-06-01), 207-210 1865-7257 6:3<207 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer