naa a22 4500 510813852 CHVBK 20180411083455.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12328-013-0388-8 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0388-8 Gastric crystal-storing histiocytosis detected with asymptomatic Sjögren's syndrome: report of a case and summary [Elektronische Daten] [Yutaka Yano, Takashi Nagahama, Toshiyuki Matsui, Kenta Chuman, Masao Takeichi, Fumihito Hirai, Kenshi Yao, Nobuaki Nishimata, Seiji Haraoka, Akinori Iwashita] Crystal-storing histiocytosis (CSH) localized to the stomach is very rare, with only two cases reported to date. The present patient was a 55-year-old woman with no noteworthy symptoms. An area of discoloration was seen in the greater curvature of the gastric body on upper endoscopy by a local physician, and CSH was strongly suspected on biopsy examination. On upper endoscopy performed at our hospital, a flat, whitish, finely granular membrane with a diameter of 10mm was seen in the greater curvature of the gastric body on white light observation. On magnifying endoscopy of the focal site, white granular material could be seen in the subepithelium, and the surface layer microvascular architecture image seen below the mucosal subepithelium was similar to the background, suggesting localization of the white material in a deep mucosal layer. On endoscopic ultrasound, this was depicted as multiple hyperechoic spots within the second layer corresponding to the involved area. Endoscopic submucosal dissection (ESD) was performed for a definitive diagnosis. Histopathological assessment of resected specimens revealed infiltration of abundant histiocytes including acidophilic crystalline structured material and positive plasma cells on anti-κ chain immunostaining, and CSH was diagnosed. Since this patient could have had a concomitant background autoimmune or hematologic disease, a systemic search was done. During this search, comorbid Sjögren's syndrome was discovered. This case of asymptomatic Sjögren's syndrome discovered during investigation of very rare gastric CHS is reported. Springer Japan, 2013 Crystal-Storing Histiocytosis (CSH) nationallicence Stomach nationallicence Localized nationallicence Sjögren's syndrome nationallicence Esophagogastroduodenoscopy (EGD) nationallicence Yano Yutaka Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut Nagahama Takashi Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut Matsui Toshiyuki Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut Chuman Kenta Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut Takeichi Masao Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut Hirai Fumihito Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut Yao Kenshi Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut Nishimata Nobuaki Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan aut Haraoka Seiji Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan aut Iwashita Akinori Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/3(2013-06-01), 237-242 1865-7257 6:3<237 2013 6 12328 https://doi.org/10.1007/s12328-013-0388-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0388-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yano Yutaka Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut NATIONALLICENCE 700 1- Nagahama Takashi Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut NATIONALLICENCE 700 1- Matsui Toshiyuki Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut NATIONALLICENCE 700 1- Chuman Kenta Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut NATIONALLICENCE 700 1- Takeichi Masao Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut NATIONALLICENCE 700 1- Hirai Fumihito Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut NATIONALLICENCE 700 1- Yao Kenshi Department of Gastroenterology, Fukuoka University Chikushi Hospital, Zokumyoin 1-1-1, Chikushino, 818-8502, Fukuoka, Japan aut NATIONALLICENCE 700 1- Nishimata Nobuaki Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Haraoka Seiji Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Iwashita Akinori Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/3(2013-06-01), 237-242 1865-7257 6:3<237 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer