naa a22 4500 510813879 CHVBK 20180411083455.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12328-013-0380-3 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0380-3 Primary amelanotic malignant melanoma of the small intestine diagnosed by esophagogastroduodenoscopy before surgical resection [Elektronische Daten] [Takanori Suganuma, Junko Fujisaki, Toshiaki Hirasawa, Akiyosi Ishiyama, Yorimasa Yamamoto, Tomohiro Tsuchida, Masahiro Igarashi] A 67-year-old man, presenting with anemia and suspected gastric cancer, was referred to our hospital, where he underwent esophagogastroduodenoscopy (EGD). Biopsy revealed densely populated semi-circular cells with abundant cytoplasm that were positive for S-100 protein, melanoma antigen, and HMB-45, resulting in a diagnosis of malignant melanoma. A gastrointestinal barium study for further exploration demonstrated a filling defect 6cm in size at the ligament of Treitz. Follow-up EGD of this finding revealed an ulcerated, half-circumferential lesion with a distinct ulcer mound extending from the ascending part of the duodenum to the jejunum, and additional biopsy also indicated malignant melanoma. Computed tomography scans showed wall thickening from the ascending part of duodenum to the proximal jejunum, whereas positron emission tomography revealed accumulation at the upper gastric body, the duodenum to the jejunum, and the left adrenal gland. Systemic exploration of the patient, including the skin, anus, and eyeballs, revealed no other lesions, and primary small intestinal malignant melanoma with metastasis to the stomach and adrenal gland was diagnosed. Partial duodenojejunectomy, partial gastrectomy, and left adrenalectomy were performed, and adjuvant chemotherapy with dacarbazine, nimustine hydrochloride, and vincristine sulfate was administered. No postoperative recurrence has been observed in the past 3years. The Author(s), 2013 AMM nationallicence Melanoma nationallicence DAV nationallicence Small intestine nationallicence Suganuma Takanori Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut Fujisaki Junko Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut Hirasawa Toshiaki Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut Ishiyama Akiyosi Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut Yamamoto Yorimasa Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut Tsuchida Tomohiro Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut Igarashi Masahiro Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/3(2013-06-01), 211-216 1865-7257 6:3<211 2013 6 12328 https://doi.org/10.1007/s12328-013-0380-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0380-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suganuma Takanori Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujisaki Junko Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Hirasawa Toshiaki Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Ishiyama Akiyosi Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamamoto Yorimasa Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Tsuchida Tomohiro Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Igarashi Masahiro Department of Gastroenterology, Cancer Institute Ariake Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/3(2013-06-01), 211-216 1865-7257 6:3<211 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer