naa a22 4500 510813941 CHVBK 20180411083456.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12328-013-0410-1 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0410-1 Adiponectin in chronic hepatitis C [Elektronische Daten] [Toru Arano, Hayato Nakagawa, Hitoshi Ikeda, Kazuhiko Koike] White adipose tissue has been increasingly recognized as an important endocrine organ that secretes a number of biologically active adipokines. Adiponectin, one of the major adipokines, possesses anti-inflammatory and insulin-sensitizing properties, and its serum levels typically decline with increasing body weight. Hypoadiponectinemia has been implicated in the development of obesity-related morbidities such as dyslipidemia and cerebrovascular disease. In addition, hypoadiponectinemia has been reported to enhance hepatic steatosis, inflammation, fibrosis, and hepatocarcinogenesis in animal models or clinical liver diseases. Chronic hepatitis C (CHC) has some features which allow it to be recognized not only as a viral disease but also as a metabolic liver disease that encompasses insulin resistance, inflammation, steatosis and fibrosis. CHC is another disease in which adipokines may represent a link between viral infection and steatosis, or metabolic disturbance. In this report, data indicating a possible role of adiponectin in CHC are summarized. Springer Japan, 2013 Adiponectin nationallicence Chronic hepatitis C nationallicence Hepatocellular carcinoma nationallicence Arano Toru Department of Gastroenterology, Toshiba General Hospital, 6-3-22 Higashi-ooi, Shinagawa-ku, 140-8522, Tokyo, Japan aut Nakagawa Hayato Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Ikeda Hitoshi Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Koike Kazuhiko Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/4(2013-08-01), 259-263 1865-7257 6:4<259 2013 6 12328 https://doi.org/10.1007/s12328-013-0410-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0410-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arano Toru Department of Gastroenterology, Toshiba General Hospital, 6-3-22 Higashi-ooi, Shinagawa-ku, 140-8522, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakagawa Hayato Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Ikeda Hitoshi Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Koike Kazuhiko Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/4(2013-08-01), 259-263 1865-7257 6:4<259 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer