naa a22 4500 510814069 CHVBK 20180411083456.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12328-013-0409-7 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0409-7 Upper gastrointestinal complications induced by anti-platelet agents [Elektronische Daten] [Takashi Kawai, Hiroko Sugimoto, Mari Fukuzawa, Masakatsu Fukuzawa, Chika Kusano, Takuji Gotoda, Fuminori Moriyasu] Low-dose aspirin and thienopyridine are associated with gastrointestinal (GI) complications such as petechiae, erosion, ulcer, bleeding, and perforation. The incidence of GI bleeding in aspirin study groups was 0.82% in the hypertension optimal treatment (HOT) study and 0.76% in the primary prevention project (PPP) study. On the other hand, the incidence of GI bleeding by endoscopic evaluation was higher than in an observational study. In a study of 187 patients receiving low-dose aspirin for prevention of cardiovascular disease, the prevalence of endoscopically detected GI ulcers was 11% (95% CI 6.3-15.1%). Several risk factors for GI bleeding (history of peptic ulcer or GI bleeding, high aspirin dose, concomitant use of non-steroidal anti-inflammatory drugs and anti-platelet agents, advanced age and Helicobacter pylori infection) were reported for patients receiving aspirin. Prevention strategies for GI complications induced by anti-platelet agents are treatment with proton pump inhibitors, histamine-2 receptor antagonists, prostaglandin analogs, prostaglandin inducers and H. pylori eradication therapy. Further investigation is necessary to identify the strategies which are suitable for Japan. Springer Japan, 2013 Low-dose aspirin nationallicence H. pylori infection nationallicence Gastrointestinal damage nationallicence Proton pump inhibitor nationallicence Adaptation nationallicence Kawai Takashi Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan aut Sugimoto Hiroko Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan aut Fukuzawa Mari Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan aut Fukuzawa Masakatsu 4th Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan aut Kusano Chika 4th Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan aut Gotoda Takuji 4th Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan aut Moriyasu Fuminori 4th Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/4(2013-08-01), 264-268 1865-7257 6:4<264 2013 6 12328 https://doi.org/10.1007/s12328-013-0409-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0409-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawai Takashi Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Sugimoto Hiroko Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Fukuzawa Mari Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Fukuzawa Masakatsu 4th Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan aut NATIONALLICENCE 700 1- Kusano Chika 4th Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan aut NATIONALLICENCE 700 1- Gotoda Takuji 4th Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan aut NATIONALLICENCE 700 1- Moriyasu Fuminori 4th Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/4(2013-08-01), 264-268 1865-7257 6:4<264 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer