naa a22 4500 510814077 CHVBK 20180411083456.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12328-013-0384-z doi (NATIONALLICENCE)springer-10.1007/s12328-013-0384-z Hepatocellular carcinoma metastasis to the brain mimicking primary pituitary tumor around the sella turcica [Elektronische Daten] [Tetsuo Tamura, Yusuke Kawamura, Kenji Ikeda, Yuya Seko, Taito Fukushima, Hiromitu Kumada, Shozo Yamada, Yuji Matumaru] We report on two cases of hepatocellular carcinoma (HCC) with metastasis to the cavernous sinus and sphenoid sinus. Both cases presented with diplopia and retro-orbital headache and both underwent surgery for a primary pituitary gland tumor. After surgery, both cases were diagnosed with metastases from HCC. Case 1 was a 67-year-old male with a history of HCC who was referred to our hospital for pituitary tumor surgery. The tumor appeared to be in the sella turcica and to invade the sphenoid sinus and right cavernous sinus. Transnasal transsphenoidal surgery (TSS) was performed. The tumor was postoperatively diagnosed by histology to be a metastatic pituitary tumor from HCC. Radiotherapy was administered to the metastatic site. Case 2 was a 58-year-old male with a history of TSS for a pituitary tumor 16years previously. He was referred to our hospital for TSS for a recurrent pituitary adenoma. TSS was performed twice in 3months. During a preoperative general examination, HCC and chronic hepatitis B were revealed. TSS was performed initially, followed by arterial infusion chemotherapy. After TSS, the pituitary tumor was diagnosed by histology to be a metastasis from HCC. As with Case 1, radiotherapy was administered to the metastasis. Most tumors in the sella turcica are pituitary adenomas, although some cases of metastatic pituitary tumors and skull base metastases have been reported. Distant metastases generally have a poor prognosis; however, surgery to the metastatic site can effectively control symptoms caused by the metastatic tumor. Springer Japan, 2013 Hepatocellular carcinoma nationallicence Metastatic pituitary tumor nationallicence Skull base metastasis nationallicence Tamura Tetsuo Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Kawamura Yusuke Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Ikeda Kenji Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Seko Yuya Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Fukushima Taito Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Kumada Hiromitu Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Yamada Shozo Department of Neurosurgery, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Matumaru Yuji Department of Endovascular Neurosurgery, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/4(2013-08-01), 319-325 1865-7257 6:4<319 2013 6 12328 https://doi.org/10.1007/s12328-013-0384-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0384-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tamura Tetsuo Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Kawamura Yusuke Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Ikeda Kenji Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Seko Yuya Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Fukushima Taito Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Kumada Hiromitu Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamada Shozo Department of Neurosurgery, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 700 1- Matumaru Yuji Department of Endovascular Neurosurgery, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, 105-8470, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/4(2013-08-01), 319-325 1865-7257 6:4<319 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer