naa a22 4500 51081414X CHVBK 20180411083456.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12328-013-0402-1 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0402-1 A pediatric case of hepatitis B virus subgenotype A2 in Japan [Elektronische Daten] [Kazuhiko Hayashi, Masatoshi Ishigami, Yoji Ishizu, Teiji Kuzuya, Takashi Honda, Akihiro Itoh, Yoshiki Hirooka, Tetsuya Ishikawa, Isao Nakano, Yoshinori Ito, Hiroshi Kimura, Yoshiaki Katano, Hidemi Goto] Hepatitis B virus (HBV) has been classified into 10 major genotypes, and HBV genotypes C and B are found in the majority of Japanese patients. However, the prevalence of genotype A has been increasing in patients with chronic or acute hepatitis. Here we report a pediatric case of HBV subgenotype A2. A 2-year-old girl was referred to our hospital for liver damage caused by HBV infection. During the pregnancy, her father had developed acute sporadic hepatitis B. The child was born without any complications. She did not receive HBV vaccination at birth because her mother was negative for HBs antigen at the pre-delivery screening; however, her mother developed acute hepatitis B 2months after delivery. At that time, HBs antigen was detected in the current patient. Phylogenetic full-length sequence analysis revealed HBV subgenotype A2. HBV sequencing was not performed for her parents; therefore, the intrafamilial transmission routes in these cases are unclear, although the authors speculate that, for the current patient, mother-to-child transmission may have occurred. This report illustrates the pitfalls of the selective vaccination strategy in Japan for preventing HBV infection. Universal vaccination to prevent HBV infection might be useful in Japan. Springer Japan, 2013 Hepatitis B virus nationallicence HBV genotype A nationallicence Universal vaccination nationallicence Hayashi Kazuhiko Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Ishigami Masatoshi Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Ishizu Yoji Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Kuzuya Teiji Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Honda Takashi Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Itoh Akihiro Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Hirooka Yoshiki Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Ishikawa Tetsuya Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Nakano Isao Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Ito Yoshinori Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Kimura Hiroshi Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Katano Yoshiaki Department of Internal Medicine, Banbuntane Hotokukai Hospital, Fujita Health University, School of Medicine, 3-6-10 Otobashi, Nakagawa-ku, 454-8509, Nagoya, Japan aut Goto Hidemi Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/5(2013-10-01), 383-385 1865-7257 6:5<383 2013 6 12328 https://doi.org/10.1007/s12328-013-0402-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0402-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hayashi Kazuhiko Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Ishigami Masatoshi Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Ishizu Yoji Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Kuzuya Teiji Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Honda Takashi Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Itoh Akihiro Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Hirooka Yoshiki Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Ishikawa Tetsuya Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Nakano Isao Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Ito Yoshinori Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Kimura Hiroshi Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Katano Yoshiaki Department of Internal Medicine, Banbuntane Hotokukai Hospital, Fujita Health University, School of Medicine, 3-6-10 Otobashi, Nakagawa-ku, 454-8509, Nagoya, Japan aut NATIONALLICENCE 700 1- Goto Hidemi Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/5(2013-10-01), 383-385 1865-7257 6:5<383 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer