naa a22 4500 510814220 CHVBK 20180411083457.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12328-013-0359-0 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0359-0 Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis [Elektronische Daten] [Akiko Hisamochi, Masayoshi Kage, Teruko Arinaga, Tatsuya Ide, Ichiro Miyajima, Kei Ogata, Reiichiro Kuwahara, Yuriko Koga, Ryukichi Kumashiro, Michio Sata] Agaricus blazei Murill (ABM) is one of the most popular complementary alternative medicines (CAM). We experienced a case of a 60-year-old woman with severe hepatitis associated with extract of ABM and extract of Ganoderma lucidum, and a case of a 75-year-old man with drug-induced liver injury (DILI) associated with extract of ABM and fucoidan. Their clinical courses from the start of CAM until the onset of DILI were observed unexpectedly, because they were under observation for stable malignant neoplasms: stage III malignant thymoma and stage IV lung cancer, respectively. However, they did not talk about taking CAM with their physicians. There were two common points between these two cases. First, they were diagnosed as compatible with DILI by using an international diagnostic scale, the Roussel Uclaf Causality Assessment Method. The second point was that histological findings of the liver were very similar to autoimmune hepatitis (AIH). In addition, serum immunoglobulin G and zinc sulfate turbidity tests gradually increased from the start of CAM to the onset of DILI. Their clinical course and liver histology suggested that the immunostimulating action of ABM caused liver injury which was very similar to that seen in AIH. Springer Japan, 2013 Drug-induced liver injury nationallicence Autoimmune hepatitis nationallicence Liver histology nationallicence Agaricus blazei Murill nationallicence Complementary alternative medicines nationallicence Hisamochi Akiko Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Kage Masayoshi The Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Arinaga Teruko Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Ide Tatsuya Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Miyajima Ichiro Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Ogata Kei Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Kuwahara Reiichiro Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Koga Yuriko Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Kumashiro Ryukichi Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Sata Michio Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 139-144 1865-7257 6:2<139 2013 6 12328 https://doi.org/10.1007/s12328-013-0359-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0359-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hisamochi Akiko Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kage Masayoshi The Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 700 1- Arinaga Teruko Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 700 1- Ide Tatsuya Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 700 1- Miyajima Ichiro Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 700 1- Ogata Kei Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kuwahara Reiichiro Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 700 1- Koga Yuriko Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kumashiro Ryukichi Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sata Michio Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011, Kurume, Fukuoka, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 139-144 1865-7257 6:2<139 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer