naa a22 4500 510814255 CHVBK 20180411083457.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12328-013-0368-z doi (NATIONALLICENCE)springer-10.1007/s12328-013-0368-z Pancreatic intraepithelial neoplasia-3 with localized acute pancreatitis in the main pancreatic duct [Elektronische Daten] [Takaho Okada, Fuyuhiko Motoi, Atsushi Kanno, Atsushi Masamune, Kazuyuki Ishida, Fumiyoshi Fujishima, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Tooru Shimosegawa, Michiaki Unno] Pancreatic intraepithelial neoplasia (PanIN) is one of the most important issues for the early detection of pancreatic ductal adenocarcinoma. In particular, PanIN-3 is recognized as a precancerous lesion, e.g., carcinoma in situ, high-grade dysplasia, and severe dysplasia. We report a rare, completely resected case of PanIN-3 in the main pancreatic duct (MPD) detected from localized pancreatitis. A 63-year-old man developed upper abdominal pain with hyperamylasemia. He underwent distal pancreatectomy soon after recovery because an abnormal narrow segment, suggesting PanIN, was identified in the pancreatic body by endoscopic retrograde cholangiopancreatography. Histopathological findings revealed a PanIN-3 located in the MPD that could be resected completely. This finding suggests that if unidentified localized pancreatitis develops, we should carefully examine the fine structural changes in the MPD. Springer Japan, 2013 Early pancreatic cancer nationallicence PanIN-3 nationallicence Acute pancreatitis nationallicence Okada Takaho Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut Motoi Fuyuhiko Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut Kanno Atsushi Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Masamune Atsushi Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Ishida Kazuyuki Department of Pathology, Tohoku University Hospital, Sendai, Japan aut Fujishima Fumiyoshi Department of Pathology, Tohoku University Hospital, Sendai, Japan aut Rikiyama Toshiki Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut Katayose Yu Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut Egawa Shinichi Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut Shimosegawa Tooru Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Unno Michiaki Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 164-168 1865-7257 6:2<164 2013 6 12328 https://doi.org/10.1007/s12328-013-0368-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0368-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okada Takaho Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Motoi Fuyuhiko Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Kanno Atsushi Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Masamune Atsushi Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Ishida Kazuyuki Department of Pathology, Tohoku University Hospital, Sendai, Japan aut NATIONALLICENCE 700 1- Fujishima Fumiyoshi Department of Pathology, Tohoku University Hospital, Sendai, Japan aut NATIONALLICENCE 700 1- Rikiyama Toshiki Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Katayose Yu Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Egawa Shinichi Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Shimosegawa Tooru Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Unno Michiaki Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 164-168 1865-7257 6:2<164 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer