naa a22 4500 510814263 CHVBK 20180411083457.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12328-013-0370-5 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0370-5 A pregnant woman with acute hepatitis B in whom vertical transmission was prevented by tenofovir disoproxil fumarate [Elektronische Daten] [Madoka Tooyama, Akihiro Tamori, Akemi Nakano, Hoang Hai, Le Thuy, Masaru Enomoto, Norifumi Kawada] The optimal management of acute hepatitis B in pregnant women remains to be fully evaluated. A case of hepatitis B virus (HBV) infection in a 20-year-old pregnant woman who initially presented with jaundice is reported. Serum samples were positive for anti-HBc IgM and HBe antigen. Her husband was infected with HBV genotype A and received entecavir because of prolonged hepatitis and a high viral load. The HBV DNA sequence of the wife completely matched that of her husband, indicating that he was the source of HBV infection. In accordance with guidelines for the treatment of chronic HBV carriers, the wife started to receive tenofovir disoproxil fumarate (TDF) in her third trimester. After 4months of treatment, the HBV DNA load decreased from 7.6 to 3.5log copies/ml. At delivery, the serum was found negative for the HBe antigen. Seven months after treatment began, the HBs antigens also disappeared. The baby, totally healthy, received passive-active immunoprophylaxis. At 3months, the baby remained free of HBV infection. TDF thus prevented exacerbation and prolongation of acute HBV infection in a pregnant woman. Subsequent treatment also prevented mother-to-infant transmission of HBV. The clinical course of her husband, who had HBV infection and received entecavir, is also reported. Springer Japan, 2013 Hepatitis B virus nationallicence Mother-to-infant HBV transmission nationallicence Tenofovir disoproxil fumarate nationallicence Tooyama Madoka Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut Tamori Akihiro Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut Nakano Akemi Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan aut Hai Hoang Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut Thuy Le Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut Enomoto Masaru Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut Kawada Norifumi Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 173-176 1865-7257 6:2<173 2013 6 12328 https://doi.org/10.1007/s12328-013-0370-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0370-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tooyama Madoka Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut NATIONALLICENCE 700 1- Tamori Akihiro Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut NATIONALLICENCE 700 1- Nakano Akemi Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Hai Hoang Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut NATIONALLICENCE 700 1- Thuy Le Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut NATIONALLICENCE 700 1- Enomoto Masaru Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut NATIONALLICENCE 700 1- Kawada Norifumi Department of Hepatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abenoku, Osaka, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 173-176 1865-7257 6:2<173 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer