naa a22 4500 51081428X CHVBK 20180411083457.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12328-013-0371-4 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0371-4 Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier [Elektronische Daten] [Shinta Mizuno, Yoshiyuki Yamagishi, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Mai Katahira, Aya Sasaki, Michiie Sakamoto, Hidekazu Suzuki, Takanori Kanai, Toshifumi Hibi] A 58-year-old man was diagnosed as a hepatitis B virus (HBV) carrier approximately 30years ago. He was diagnosed with renal cell carcinoma when he was 57years old. Radical nephrectomy was performed, and everolimus was administered to treat his lung metastasis. After beginning the everolimus, intermittent fever, general fatigue, and jaundice developed. He was admitted under a diagnosis of flare (acute exacerbation) of chronic B hepatitis due to HBV reactivation. Despite intensive care, he died of hepatic failure and fungus infection. The autopsy findings were compatible with hepatic failure due to HBV reactivation by everolimus. Antiviral prophylaxis must be taken into consideration before beginning immunosuppressive therapy such as everolimus in HBV carriers. The Author(s), 2013 Everolimus nationallicence Immunosuppressive therapy nationallicence Hepatitis B virus nationallicence Liver failure nationallicence Nucleoside analogue nationallicence Mizuno Shinta Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut Yamagishi Yoshiyuki Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut Ebinuma Hirotoshi Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut Nakamoto Nobuhiro Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut Katahira Mai Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut Sasaki Aya Department of Pathology, Keio University School of Medicine Shinanomachi, Shinjuku-ku, Tokyo, Japan aut Sakamoto Michiie Department of Pathology, Keio University School of Medicine Shinanomachi, Shinjuku-ku, Tokyo, Japan aut Suzuki Hidekazu Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut Kanai Takanori Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut Hibi Toshifumi Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 188-192 1865-7257 6:2<188 2013 6 12328 https://doi.org/10.1007/s12328-013-0371-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0371-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mizuno Shinta Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamagishi Yoshiyuki Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Ebinuma Hirotoshi Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamoto Nobuhiro Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Katahira Mai Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Sasaki Aya Department of Pathology, Keio University School of Medicine Shinanomachi, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakamoto Michiie Department of Pathology, Keio University School of Medicine Shinanomachi, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Suzuki Hidekazu Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Kanai Takanori Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Hibi Toshifumi Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 160-8582, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 188-192 1865-7257 6:2<188 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer