naa a22 4500 510814301 CHVBK 20180411083457.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12328-013-0374-1 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0374-1 Stage IV intramucosal gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type [Elektronische Daten] [Masahiko Ohtaka, Tadashi Sato, Shouji Kobayashi, Ryouta Sueki, Tatsuya Yamaguchi, Tomoyoshi Uetake, Hiroyuki Ohtsuka, Noriaki Iwao, Keita Kirito, Nobuyuki Enomoto] A 45-year-old woman with no symptoms underwent upper gastrointestinal endoscopy. A discolored area was noted at the greater curvature of the gastric upper body. Endoscopic ultrasonography demonstrated thickening of the second sonographic layer indicating that the depth of invasion was confined to the mucosa. A urea breath test and anti-Helicobacter pylori antibody test were negative. A computed tomography scan showed a consolidation at the right lung. Gastric biopsy and transbronchial lung biopsy (TBLB) demonstrated a monotonous proliferation of atypical small lymphocytes. A diagnosis of gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma) was made. The clinical stage was stage IV. A genetic analysis showed rearrangement of the joining region of the immunoglobulin heavy chain gene and identical clones in both lesions. An API2-MALT1 fusion gene was detected in the gastric lesion. After H. pylori eradication treatment, combination treatment with rituximab plus CHOP (R-CHOP) was performed; 6months later an endoscopy revealed complete disappearance of the lesion. Multiple gastric biopsies showed no infiltrating atypical lymphocytes. Similarly, the lesion in the lung showed complete remission (CR) on CT and TBLB. This report shows that a gastric MALT lymphoma located in the mucosa and disseminated to the lung maintained CR by R-CHOP. Springer Japan, 2013 Intramucosal gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type nationallicence Stage IV nationallicence Lung involvement nationallicence API2 - MALT1 fusion gene nationallicence R-CHOP nationallicence Ohtaka Masahiko First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut Sato Tadashi First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut Kobayashi Shouji First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut Sueki Ryouta First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut Yamaguchi Tatsuya First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut Uetake Tomoyoshi First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut Ohtsuka Hiroyuki First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut Iwao Noriaki Department of Hematology, University of Yamanashi, Chuo, Japan aut Kirito Keita Department of Hematology, University of Yamanashi, Chuo, Japan aut Enomoto Nobuyuki First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 127-133 1865-7257 6:2<127 2013 6 12328 https://doi.org/10.1007/s12328-013-0374-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0374-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohtaka Masahiko First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut NATIONALLICENCE 700 1- Sato Tadashi First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut NATIONALLICENCE 700 1- Kobayashi Shouji First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut NATIONALLICENCE 700 1- Sueki Ryouta First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut NATIONALLICENCE 700 1- Yamaguchi Tatsuya First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut NATIONALLICENCE 700 1- Uetake Tomoyoshi First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut NATIONALLICENCE 700 1- Ohtsuka Hiroyuki First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut NATIONALLICENCE 700 1- Iwao Noriaki Department of Hematology, University of Yamanashi, Chuo, Japan aut NATIONALLICENCE 700 1- Kirito Keita Department of Hematology, University of Yamanashi, Chuo, Japan aut NATIONALLICENCE 700 1- Enomoto Nobuyuki First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo, Yamanashi, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 127-133 1865-7257 6:2<127 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer