naa a22 4500 510814328 CHVBK 20180411083458.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12328-013-0366-1 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0366-1 Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient [Elektronische Daten] [Tatsuo Kanda, Shingo Nakamoto, Makoto Arai, Tatsuo Miyamura, Shuang Wu, Keiichi Fujiwara, Osamu Yokosuka] We describe a patient infected with hepatitis C virus (HCV) genotype 1 who failed to respond to interferon with or without ribavirin seven times but who then achieved sustained virological response by the combination of interferon-beta plus ribavirin treatment for 48weeks. He did not respond to stronger treatment such as prolonged peginterferon plus ribavirin treatment for 87weeks. It might be rare to treat a patient with interferon 8 times considering the cost and time, since patients failing interferon treatment several times are regarded to be refractory to interferon. It is possible that the difference in biological effects between interferon-alfa and interferon-beta might have resulted in a different outcome in our patient. Interferon-beta plus ribavirin therapy might be one of the treatment options for certain patients chronically infected with HCV who do not respond to standard care treatment. Springer Japan, 2013 Hepatitis C nationallicence HCV genotype 1 nationallicence Interferon-beta nationallicence Neutralizing antibody nationallicence Ribavirin nationallicence Sustained virological response nationallicence Kanda Tatsuo Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut Nakamoto Shingo Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut Arai Makoto Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut Miyamura Tatsuo Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut Wu Shuang Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut Fujiwara Keiichi Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut Yokosuka Osamu Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 160-163 1865-7257 6:2<160 2013 6 12328 https://doi.org/10.1007/s12328-013-0366-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0366-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kanda Tatsuo Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut NATIONALLICENCE 700 1- Nakamoto Shingo Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut NATIONALLICENCE 700 1- Arai Makoto Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut NATIONALLICENCE 700 1- Miyamura Tatsuo Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut NATIONALLICENCE 700 1- Wu Shuang Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut NATIONALLICENCE 700 1- Fujiwara Keiichi Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut NATIONALLICENCE 700 1- Yokosuka Osamu Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8677, Chiba, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 160-163 1865-7257 6:2<160 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer