naa a22 4500 510814379 CHVBK 20180411083458.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12328-013-0365-2 doi (NATIONALLICENCE)springer-10.1007/s12328-013-0365-2 Imatinib therapy for a patient with metastasis of colonic gastrointestinal stromal tumor: report of a case [Elektronische Daten] [Takuma Okamura, Tatsuo Kanda, Seiichi Hirota, Atsushi Nishimura, Mikako Kawahara, Keiya Nikkuni] Gastrointestinal stromal tumors (GISTs) developing in the colon are rare, accounting for <5% of all GISTs. There are few data on the clinical efficacy of tyrosine kinase inhibitors in colonic GISTs. We report here on an 80-year-old male patient with advanced GIST of the transverse colon. The patient underwent palliative resection of the primary tumor because the disease was associated with multiple liver metastases and peritoneal dissemination. Immunohistochemical analysis of the surgical specimens showed KIT and CD34 expression. Sequence analysis revealed that the tumor harbored deletion mutation at codons 557-558 in exon 11 of the c-kit gene. A diagnosis of colonic GIST was made. The patient postoperatively underwent imatinib therapy for the remaining metastatic tumors. Imatinib therapy induced a cyst-like appearance of the liver metastases and stabilized the disease. In the present case, c-kit gene analysis was found to be clinically helpful for validating the diagnosis and therapeutic decision making for this rare disease. The Author(s), 2013 Colon nationallicence Gene analysis nationallicence GIST nationallicence Imatinib nationallicence KIT nationallicence Okamura Takuma Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut Kanda Tatsuo Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut Hirota Seiichi Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan aut Nishimura Atsushi Department of Surgery, Nagaoka Chuo General Hospital, Nagaoka, Japan aut Kawahara Mikako Department of Surgery, Nagaoka Chuo General Hospital, Nagaoka, Japan aut Nikkuni Keiya Department of Surgery, Nagaoka Chuo General Hospital, Nagaoka, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 116-121 1865-7257 6:2<116 2013 6 12328 https://doi.org/10.1007/s12328-013-0365-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0365-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okamura Takuma Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Kanda Tatsuo Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan aut NATIONALLICENCE 700 1- Hirota Seiichi Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan aut NATIONALLICENCE 700 1- Nishimura Atsushi Department of Surgery, Nagaoka Chuo General Hospital, Nagaoka, Japan aut NATIONALLICENCE 700 1- Kawahara Mikako Department of Surgery, Nagaoka Chuo General Hospital, Nagaoka, Japan aut NATIONALLICENCE 700 1- Nikkuni Keiya Department of Surgery, Nagaoka Chuo General Hospital, Nagaoka, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 116-121 1865-7257 6:2<116 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer