naa a22 4500 510814409 CHVBK 20180411083458.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12328-013-0376-z doi (NATIONALLICENCE)springer-10.1007/s12328-013-0376-z Gastric cancers with microsatellite instability sharing clinical features, chemoresistance and germline MSH6 variants [Elektronische Daten] [Kentaro Yamashita, Yoshiaki Arimura, Mayuko Saito, Hiromu Suzuki, Tomohisa Furuhata, Koichi Hirata, Yasuhisa Shinomura] Recent studies suggest that colorectal cancer with microsatellite instability (MSI) might be resistant to fluorouracil-based chemotherapy; however, little is known about the clinical significance of MSI analysis for gastric cancer. We therefore conducted a prospective single center study analyzing MSI in gastric cancer. Of 123 consecutive gastric cancers analyzed, 12 (9.8%) were MSI-positive and two patients with MSI-positive gastric cancer underwent systemic chemotherapy because of unresectable disease. Neither cases had concurrent nor past history of other malignancies but one had cancer family history meeting the revised Bethesda criteria. These two MSI-positive gastric cancers shared multiple clinical features, such as direct invasion to adjacent organs, extensive nodal metastasis but no distant metastasis, resistance to fluorouracil and death of tumor bleeding. The two cases had unmethylated MLH1 promoter, suggestive of Lynch syndrome. Germline mutation analysis demonstrated MSH6 alterations of unknown significance in both cases. Springer Japan, 2013 Gastric cancer nationallicence Microsatellite instability nationallicence Lynch syndrome nationallicence Yamashita Kentaro First Department of Internal Medicine, Sapporo Medical University, S1W16, Chuo-ku, 060-8543, Sapporo, Japan aut Arimura Yoshiaki First Department of Internal Medicine, Sapporo Medical University, S1W16, Chuo-ku, 060-8543, Sapporo, Japan aut Saito Mayuko First Department of Internal Medicine, Sapporo Medical University, S1W16, Chuo-ku, 060-8543, Sapporo, Japan aut Suzuki Hiromu Department of Molecular Biology, Sapporo Medical University, Sapporo, Japan aut Furuhata Tomohisa First Department of Surgery, Sapporo Medical University, Sapporo, Japan aut Hirata Koichi First Department of Surgery, Sapporo Medical University, Sapporo, Japan aut Shinomura Yasuhisa First Department of Internal Medicine, Sapporo Medical University, S1W16, Chuo-ku, 060-8543, Sapporo, Japan aut Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 122-126 1865-7257 6:2<122 2013 6 12328 https://doi.org/10.1007/s12328-013-0376-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12328-013-0376-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamashita Kentaro First Department of Internal Medicine, Sapporo Medical University, S1W16, Chuo-ku, 060-8543, Sapporo, Japan aut NATIONALLICENCE 700 1- Arimura Yoshiaki First Department of Internal Medicine, Sapporo Medical University, S1W16, Chuo-ku, 060-8543, Sapporo, Japan aut NATIONALLICENCE 700 1- Saito Mayuko First Department of Internal Medicine, Sapporo Medical University, S1W16, Chuo-ku, 060-8543, Sapporo, Japan aut NATIONALLICENCE 700 1- Suzuki Hiromu Department of Molecular Biology, Sapporo Medical University, Sapporo, Japan aut NATIONALLICENCE 700 1- Furuhata Tomohisa First Department of Surgery, Sapporo Medical University, Sapporo, Japan aut NATIONALLICENCE 700 1- Hirata Koichi First Department of Surgery, Sapporo Medical University, Sapporo, Japan aut NATIONALLICENCE 700 1- Shinomura Yasuhisa First Department of Internal Medicine, Sapporo Medical University, S1W16, Chuo-ku, 060-8543, Sapporo, Japan aut NATIONALLICENCE 773 0- Clinical Journal of Gastroenterology Springer Japan 6/2(2013-04-01), 122-126 1865-7257 6:2<122 2013 6 12328 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer