naa a22 4500 510816924 CHVBK 20180411083511.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11468-012-9431-8 doi (NATIONALLICENCE)springer-10.1007/s11468-012-9431-8 Trapping Proteins within Gold Nanoparticle Assemblies: Dynamically Tunable Hot-spots for Nanobiosensing [Elektronische Daten] [Abdennour Abbas, Max Fei, Limei Tian, Srikanth Singamaneni] The combination of stimuli-responsive materials with localized surface plasmon resonance nanotransducers provides new leverages in hot spot-based nanosensing. We introduce a simple and effective biodetection method based on the hydro-responsive property of (3-aminopropyl)-triethoxysilane (APTES). Gold nanoparticles were adsorbed onto hydro-responsive APTES thin film. The exposure of the film surface to an aqueous solution results in opening inter-particle gaps, allowing analyte binding. A subsequent drying of the sensor surface closes the gap by bringing the nanoparticles to the initial position, thereby trapping the analyte in the most sensitive regions (electromagnetic hot spots). In this reversible configuration, the generation and tuning of the hot spots are independent from both the presence of the analyte and the functionalization of the nanoparticles, which yields highly resolved coupled plasmon bands and provide a general and flexible nanosensing modality. Furthermore, the intensity of the hot spots can be easily and reversibly tuned to obtain picomolar sensitivity. Springer Science+Business Media, LLC, 2012 Gold nanoparticles nationallicence Localized surface plasmon resonance nationallicence Plasmon coupling nationallicence Stimuli-responsive materials nationallicence Nanobiosensors nationallicence Abbas Abdennour Department of Mechanical Engineering and Materials Science, Washington University, 63130, St. Louis, MO, USA aut Fei Max Department of Mechanical Engineering and Materials Science, Washington University, 63130, St. Louis, MO, USA aut Tian Limei Department of Mechanical Engineering and Materials Science, Washington University, 63130, St. Louis, MO, USA aut Singamaneni Srikanth Department of Mechanical Engineering and Materials Science, Washington University, 63130, St. Louis, MO, USA aut Plasmonics Springer US; http://www.springer-ny.com 8/2(2013-06-01), 537-544 1557-1955 8:2<537 2013 8 11468 https://doi.org/10.1007/s11468-012-9431-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11468-012-9431-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abbas Abdennour Department of Mechanical Engineering and Materials Science, Washington University, 63130, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Fei Max Department of Mechanical Engineering and Materials Science, Washington University, 63130, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Tian Limei Department of Mechanical Engineering and Materials Science, Washington University, 63130, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Singamaneni Srikanth Department of Mechanical Engineering and Materials Science, Washington University, 63130, St. Louis, MO, USA aut NATIONALLICENCE 773 0- Plasmonics Springer US; http://www.springer-ny.com 8/2(2013-06-01), 537-544 1557-1955 8:2<537 2013 8 11468 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer