naa a22 4500 510816983 CHVBK 20180411083512.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11468-012-9438-1 doi (NATIONALLICENCE)springer-10.1007/s11468-012-9438-1 Optimized Synthesis of PEG-Encapsulated Gold Nanorods for Improved Stability and Its Application in OCT Imaging with Enhanced Contrast [Elektronische Daten] [U. Dinish, Douglas Goh, Chit Fu, Ramaswamy Bhuvaneswari, Winston Sun, Malini Olivo] Gold nanorods (GNRs) are synthesized with a surfactant template, which often poses toxicity issues for biomedical applications. In addition, blue shift of longitudinal surface plasmon resonance (LSPR) peak of GNR is an inherent problem that needs to be addressed for time-course studies. In this work, we resolve these issues by optimizing the encapsulation of GNRs with polyethylene glycol (PEG) where biocompatibility is improved by ∼20% and blue shift over a period of 8days is reduced from 20nm in the case of CTAB-GNR to 2nm for PEG-encapsulated GNR. The encapsulated GNRs were then bioconjugated for targeted dark-field imaging of cancer cells. As an application, we also demonstrate the contrast-enhancing capability of GNRs in optical coherence tomography (OCT) imaging of tumor xenograft where the LSPR closely matches the OCT excitation wavelength. Our study proves that incorporating GNRs enhances the contrast of tumor tissue interfaces along with a considerable broadening in OCT depth profile by six times. Springer Science+Business Media, LLC, 2012 Gold nanorods nationallicence PEG encapsulation nationallicence Longitudinal surface plasmon resonance nationallicence Cytotoxicity nationallicence Contrast enhancement nationallicence OCT imaging nationallicence Dinish U. Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, 138667, Singapore, Singapore aut Goh Douglas Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, 138667, Singapore, Singapore aut Fu Chit Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, 138667, Singapore, Singapore aut Bhuvaneswari Ramaswamy Division of Medical Science, National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore, Singapore aut Sun Winston Institute of Microelectronics, Agency for Science, Technology and Research (A*STAR), 11 Science Park Road, 117685, Science Park II, Singapore aut Olivo Malini Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, 138667, Singapore, Singapore aut Plasmonics Springer US; http://www.springer-ny.com 8/2(2013-06-01), 591-598 1557-1955 8:2<591 2013 8 11468 https://doi.org/10.1007/s11468-012-9438-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11468-012-9438-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dinish U. Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, 138667, Singapore, Singapore aut NATIONALLICENCE 700 1- Goh Douglas Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, 138667, Singapore, Singapore aut NATIONALLICENCE 700 1- Fu Chit Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, 138667, Singapore, Singapore aut NATIONALLICENCE 700 1- Bhuvaneswari Ramaswamy Division of Medical Science, National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore, Singapore aut NATIONALLICENCE 700 1- Sun Winston Institute of Microelectronics, Agency for Science, Technology and Research (A*STAR), 11 Science Park Road, 117685, Science Park II, Singapore aut NATIONALLICENCE 700 1- Olivo Malini Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, 138667, Singapore, Singapore aut NATIONALLICENCE 773 0- Plasmonics Springer US; http://www.springer-ny.com 8/2(2013-06-01), 591-598 1557-1955 8:2<591 2013 8 11468 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer