naa a22 4500 510817041 CHVBK 20180411083512.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11468-012-9391-z doi (NATIONALLICENCE)springer-10.1007/s11468-012-9391-z Functionalized Plasmonic Anisotropic Nanocrystals for Multimodal Imaging of Cancer Cells [Elektronische Daten] [Atcha Kopwitthaya, Ken-Tye Yong, Andrey Kuzmin, Wing-Cheung Law, Artem Pliss, Lisa Vathy, Indrajit Roy, Paras Prasad] Nanoparticles internalized by cells are valuable probes for bioimaging. In particular, nanoparticles can be detected in "biological transmission window,” i.e., near infrared region. Here, we report a preparation of biotargeting diethylthiatricarbocyanine iodide (DTTC)-functionalized gold nanorods, utilized for detection of malignant cells. These biotargeting DTTC-functionalized gold nanorods are efficiently internalized into cultured cells and can serve as probes for surface-enhanced Raman scattering (SERS) and dark-field imaging. The robust SERS signal from malignant cells has clearly demonstrated a signature peak of DTTC in the presence of our formulation. A short acquisition time, we used in this experiment, is able to exclude bulk of Raman signal from natural cellular constituents. This signature peak will be a key of identifying cancer due to cancer-specific property of biotargeted molecule. The results are leading to promising real-time cancer detection. In addition, these multimodal probes demonstrated low toxicity in cell viability studies which enables a broad range of multiplex imaging applications. Springer Science+Business Media, LLC, 2012 In vitro nanoprobe nationallicence Multiplex imaging nationallicence SERS nationallicence Gold nanorods nationallicence Kopwitthaya Atcha Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut Yong Ken-Tye School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut Kuzmin Andrey Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut Law Wing-Cheung Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut Pliss Artem Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut Vathy Lisa Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut Roy Indrajit Department of Chemistry, University of Delhi, 110 007, Delhi, India aut Prasad Paras Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut Plasmonics Springer US; http://www.springer-ny.com 8/2(2013-06-01), 313-318 1557-1955 8:2<313 2013 8 11468 https://doi.org/10.1007/s11468-012-9391-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11468-012-9391-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kopwitthaya Atcha Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Yong Ken-Tye School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut NATIONALLICENCE 700 1- Kuzmin Andrey Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Law Wing-Cheung Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Pliss Artem Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Vathy Lisa Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Roy Indrajit Department of Chemistry, University of Delhi, 110 007, Delhi, India aut NATIONALLICENCE 700 1- Prasad Paras Institute for Laser, Photonics and Biophotonics, University at Buffalo, State University of New York, 14260-4200, Buffalo, NY, USA aut NATIONALLICENCE 773 0- Plasmonics Springer US; http://www.springer-ny.com 8/2(2013-06-01), 313-318 1557-1955 8:2<313 2013 8 11468 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer