naa a22 4500 510817939 CHVBK 20180411083517.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11468-013-9502-5 doi (NATIONALLICENCE)springer-10.1007/s11468-013-9502-5 Plasmonic Spectral Detection of Carcinoembryonic Antigen by Preventing the Direct Binding of Rhodamine 6G with Au Nanoparticles [Elektronische Daten] [Jian Zhu, Hong-wen Gao, Jian-jun Li, Jun-wu Zhao] Carcinoembryonic antigen (CEA) was used as a separator to prevent the Rhodamine 6G (R6G)-induced aggregation of colloidal gold nanoparticles. The destroyed aggregation has been monitored by measuring the absorption and resonance light scattering peaks corresponding to the longitudinal surface plasmon resonance (SPR) of the chain-like aggregated gold nanoparticles (AuNPs). It was found that the pre-adding of CEA with different concentrations to the gold colloids before mixing them with R6G could lead to the longitudinal SPR peak decrease and blue shift. By analysing the intensity changing and wavelength shifting of the absorption spectra, CEA could be detected in a linear range from 0.2 to 4ng/mL, and the limit of detection reaches to 0.1ng/mL. The sensitivity of the CEA concentration dependent shifting and quenching of the plasmonic absorption and scattering corresponding to the AuNPs aggregation presents a well potential application of biologic spectral sensing. Springer Science+Business Media New York, 2013 Carcinoembryonic antigen (CEA) nationallicence Surface plasmon resonance (SPR) nationallicence Rhodamine 6G (R6G) nationallicence Gold nanoparticles (AuNPs) nationallicence Aggregation nationallicence Absorption spectrum nationallicence Zhu Jian The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, People's Republic of China aut Gao Hong-wen The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, People's Republic of China aut Li Jian-jun The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, People's Republic of China aut Zhao Jun-wu The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, People's Republic of China aut Plasmonics Springer US; http://www.springer-ny.com 8/2(2013-06-01), 1003-1009 1557-1955 8:2<1003 2013 8 11468 https://doi.org/10.1007/s11468-013-9502-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11468-013-9502-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu Jian The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Gao Hong-wen The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Li Jian-jun The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Jun-wu The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, People's Republic of China aut NATIONALLICENCE 773 0- Plasmonics Springer US; http://www.springer-ny.com 8/2(2013-06-01), 1003-1009 1557-1955 8:2<1003 2013 8 11468 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer