naa a22 4500 510818161 CHVBK 20180411083518.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12306-013-0273-0 doi (NATIONALLICENCE)springer-10.1007/s12306-013-0273-0 Intralesional autologous mesenchymal stem cells in management of osteonecrosis of femur: a preliminary study [Elektronische Daten] [S. Rastogi, S. Sankineani, H. Nag, S. Mohanty, G. Shivanand, K. Marimuthu, R. Kumar, L. Rijal] Background: Management of early stages of osteonecrosis aims to prevent the collapse of the femoral head by attempts at restoring the vascularity of femoral head. Bone marrow-derived mononuclear cells with their angiogenic and osteogenic properties appear to have the potential to halt the disease process when injected intralesionally following core decompression. Materials and methods: Forty patients (60 hips) with stage I, II or III (ARCO system) osteonecrosis of femoral head were treated by either core decompression and isolated mononuclear cells (group A) or core decompression and unprocessed bone marrow injection (group B). The patients were followed up clinically and radiologically for a minimum of 2years. The functional outcome was assessed in terms of Harris hip score, and disease progression was assessed radiologically by comparing the preoperative and follow-up MRI at the end of 2years. Results: On 2-year follow-up, there was considerable improvement in the hip function as measured by the Harris hip score in both the groups (p=0.031). On MRI, there was a decrease in the size of the lesion in group A (p=0.03). Three of 30 hips (10.0%) in group B required total hip replacement. Conclusions: Implantation of autologous bone marrow stem cells in avascular necrosis of femoral head is a safe and effective procedure and has better outcome than bone marrow for early stage of avascular necrosis of femoral head. Istituto Ortopedico Rizzoli, 2013 Osteonecrosis nationallicence Stem cells nationallicence Mononuclear nationallicence Bone marrow nationallicence Rastogi S. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Sankineani S. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Nag H. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Mohanty S. Department of Stem Cell Facility, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Shivanand G. Department of Radiodiagnosis, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Marimuthu K. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Kumar R. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Rijal L. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut MUSCULOSKELETAL SURGERY Springer Milan 97/3(2013-12-01), 223-228 2035-5106 97:3<223 2013 97 12306 https://doi.org/10.1007/s12306-013-0273-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12306-013-0273-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rastogi S. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Sankineani S. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Nag H. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Mohanty S. Department of Stem Cell Facility, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Shivanand G. Department of Radiodiagnosis, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Marimuthu K. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Kumar R. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Rijal L. Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 773 0- MUSCULOSKELETAL SURGERY Springer Milan 97/3(2013-12-01), 223-228 2035-5106 97:3<223 2013 97 12306 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer