naa a22 4500 51081820X CHVBK 20180411083518.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12306-013-0295-7 doi (NATIONALLICENCE)springer-10.1007/s12306-013-0295-7 Endothelial dysfunction and tendinopathy: how far have we come? [Elektronische Daten] [R. Papalia, L. Moro, F. Franceschi, E. Albo, S. D'Adamio, A. Di Martino, G. Vadalà, C. Faldini, V. Denaro] Symptomatic tendon tears are one of the most important causes of pain and joint dysfunction. Among the intrinsic causes, vascularization recently gained a major role. Endothelial function is indeed a key factor, as well as vascular tone and thrombotic factors, in the regulation of vascular homeostasis and the composition of vascular wall. In this review, we studied systematically whether there is a relationship between endothelial dysfunction and tendinopathy. A literature search was performed using the isolated or combined keywords endothelial dysfunction and tendon,' ‘nitric oxide (NO) and tendinopathy,' and ‘endothelial dysfunction in tendon healing.' We identified 21 published studies. Of the selected studies, 9 were in vivo studies, 2 focusing on animals and 7 on humans, while 12 reported about in vitro evaluations, where 7 were carried out on humans and 5 on animals. The evidence about a direct relationship between tendinopathy and endothelial dysfunction is still poor. As recent studies have shown, there is no significant improvement in clinical and functional assessments after treatment with NO in patients suffering from tendinopathy in different locations. No significant differences were identified in the outcomes reported for experiment group when compared with controls treated with conventional surgical procedures or rehabilitation programs. Nitric oxide could be a marker to quantify the response of the endothelium to mechanical stress or hypoxia indicating the final balance between vasodilatating and vasoconstricting factors and their effects, but more ad stronger evidence is still needed to fully support this practice. Istituto Ortopedico Rizzoli, 2013 Tendinopathy nationallicence Endothelial dysfunction nationallicence NO nationallicence Nitric oxide nationallicence Papalia R. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut Moro L. Department of Geriatrics, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Rome, Italy aut Franceschi F. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut Albo E. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut D'Adamio S. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut Di Martino A. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut Vadalà G. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut Faldini C. Department of Rizzoli-Sicilia, Orthopaedic Service, The Rizzoli Institute and University of Bologna, Bologna, Italy aut Denaro V. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut MUSCULOSKELETAL SURGERY Springer Milan 97/3(2013-12-01), 199-209 2035-5106 97:3<199 2013 97 12306 https://doi.org/10.1007/s12306-013-0295-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12306-013-0295-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Papalia R. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 700 1- Moro L. Department of Geriatrics, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Rome, Italy aut NATIONALLICENCE 700 1- Franceschi F. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 700 1- Albo E. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 700 1- D'Adamio S. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 700 1- Di Martino A. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 700 1- Vadalà G. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 700 1- Faldini C. Department of Rizzoli-Sicilia, Orthopaedic Service, The Rizzoli Institute and University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Denaro V. Department of Orthopaedic and Trauma Surgery, CIR, Center of Integrated Research, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy aut NATIONALLICENCE 773 0- MUSCULOSKELETAL SURGERY Springer Milan 97/3(2013-12-01), 199-209 2035-5106 97:3<199 2013 97 12306 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer