naa a22 4500 510818250 CHVBK 20180411083518.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12306-013-0306-8 doi (NATIONALLICENCE)springer-10.1007/s12306-013-0306-8 Practical management of new oral anticoagulants after total hip or total knee arthroplasty [Elektronische Daten] [W. Klauser, M. Dütsch] Within the past 5years, the oral anticoagulants rivaroxaban, apixaban, and dabigatran etexilate have been approved for the prevention of venous thromboembolism in adult patients after elective hip or knee arthroplasty in the European Union and many other countries worldwide. These agents differ from the previously available anticoagulants because they selectively and directly inhibit a single factor in the coagulation cascade—rivaroxaban and apixaban inhibit Factor Xa, and dabigatran inhibits Factor IIa (thrombin)—potentially enhancing the predictability of their anticoagulant effect. Currently, although some guidelines provide recommendations for the use of rivaroxaban, dabigatran etexilate, and apixaban in clinical practice, there are still questions regarding the optimal practical management of patients receiving these agents. This article briefly reviews the practical limitations associated with conventional anticoagulants, discusses potential issues with the practical management of the newer oral anticoagulants, and provides clinical experience from a single institution where rivaroxaban and dabigatran etexilate have been used within their approved indications. The Author(s), 2013 Oral anticoagulants nationallicence Deep vein thrombosis nationallicence Hip and knee arthroplasty nationallicence Klauser W. Orthopaedic Department, Helios ENDO Klinik Hamburg, Holstenstraße 2, 22767, Hamburg, Germany aut Dütsch M. Helios ENDO Klinik, Hamburg, Germany aut MUSCULOSKELETAL SURGERY Springer Milan 97/3(2013-12-01), 189-197 2035-5106 97:3<189 2013 97 12306 https://doi.org/10.1007/s12306-013-0306-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12306-013-0306-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Klauser W. Orthopaedic Department, Helios ENDO Klinik Hamburg, Holstenstraße 2, 22767, Hamburg, Germany aut NATIONALLICENCE 700 1- Dütsch M. Helios ENDO Klinik, Hamburg, Germany aut NATIONALLICENCE 773 0- MUSCULOSKELETAL SURGERY Springer Milan 97/3(2013-12-01), 189-197 2035-5106 97:3<189 2013 97 12306 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer