naa a22 4500 51081865X CHVBK 20180411083520.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12306-013-0242-7 doi (NATIONALLICENCE)springer-10.1007/s12306-013-0242-7 One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results [Elektronische Daten] [Roberto Buda, Francesca Vannini, Marco Cavallo, Matteo Baldassarri, Deianira Luciani, Antonio Mazzotti, Camilla Pungetti, Alessandra Olivieri, Sandro Giannini] Osteochondral lesions of the knee (OLK) are a common cause of knee pain and associated diseases. A new bone-marrow-derived mesenchymal stem cells technique has been developed for the treatment of OLK. 30 patients with OLK underwent arthroscopic one-step procedure. The bone marrow was harvested from the patients' posterior iliac crest and arthroscopically implanted with a scaffold into the lesion site. Clinical inspection and MRI were performed. Mean International Knee Documentation Committee (IKDC) score before surgery was 29.9±13.2 and 85.4±4.2 at 29±4.1months (p<0.0005), while Knee injury and Osteoarthritis Outcome Score (KOOS) before surgery was 35.1±11.9 and 87.3±7.3 at 29±4.1months (p<0.0005). Control MRI and bioptic samples showed an osteochondral regeneration of the lesion site. The one-step technique appears to be a good and reliable option for treatment of OLK at three years of follow-up. Level of evidence Case series, Level IV. Istituti Ortopedici Rizzoli, 2013 Bone marrow nationallicence Osteochondral lesion nationallicence Knee nationallicence Arthroscopic nationallicence Mesenchymal nationallicence Stem cells nationallicence Buda Roberto Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut Vannini Francesca Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut Cavallo Marco Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut Baldassarri Matteo Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut Luciani Deianira Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut Mazzotti Antonio Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut Pungetti Camilla Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut Olivieri Alessandra Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut Giannini Sandro Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut MUSCULOSKELETAL SURGERY Springer Milan 97/2(2013-08-01), 145-151 2035-5106 97:2<145 2013 97 12306 https://doi.org/10.1007/s12306-013-0242-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12306-013-0242-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buda Roberto Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut NATIONALLICENCE 700 1- Vannini Francesca Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut NATIONALLICENCE 700 1- Cavallo Marco Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut NATIONALLICENCE 700 1- Baldassarri Matteo Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut NATIONALLICENCE 700 1- Luciani Deianira Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut NATIONALLICENCE 700 1- Mazzotti Antonio Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut NATIONALLICENCE 700 1- Pungetti Camilla Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut NATIONALLICENCE 700 1- Olivieri Alessandra Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut NATIONALLICENCE 700 1- Giannini Sandro Clinical Orthopaedic and Traumatology Unit I, Rizzoli Orthopaedic Institute, via G.C. Pupilli n.1, Bologna, Italy aut NATIONALLICENCE 773 0- MUSCULOSKELETAL SURGERY Springer Milan 97/2(2013-08-01), 145-151 2035-5106 97:2<145 2013 97 12306 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer