naa a22 4500 510819044 CHVBK 20180411083522.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s11814-012-0133-x doi (NATIONALLICENCE)springer-10.1007/s11814-012-0133-x Physicochemical characterization and dissolution enhancement of loratadine by solid dispersion technique [Elektronische Daten] [Suresh Bandari, Subash Jadav, Basanth Eedara, Raju Jukanti, Prabhakar Veerareddy] The purpose of this investigation was to enhance the dissolution rate of loratadine using polyethylene glycol 6000 (PEG) solid dispersions (SDs). The solubility behavior of loratadine in the presence of polyethylene glycol 4000 and polyethylene glycol 6000 in water showed linear increase with increasing concentrations of PEG, indicating A L type solubility diagrams. SDs of loratadine with PEG 6000 were prepared at 1: 1, 1: 3, 1: 5, 1: 7 and 1: 9 ratios by the solvent evaporation method. Solid dispersions were characterized for drug content, dissolution behavior and for physicochemical characteristics. The dissolution rate of loratadine was enhanced rapidly with increasing concentrations of PEG 6000 in SDs. Fourier transform infrared (FTIR) studies showed the stability of loratadine and the absence of a well-defined loratadine — PEG 6000 interaction. Differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRD) studies revealed the amorphous state of loratadine in SDs of loratadine with PEG 6000 which was further confirmed from scanning electron microscopy (SEM) studies. The flow properties of the blend, physical characteristics and disintegration time of the tablets formulated indicated that PEG 6000 SD can be used to formulate fast release loratadine tablets. Korean Institute of Chemical Engineers, Seoul, Korea, 2012 Loratadine nationallicence Phase Solubility nationallicence Polyethylene Glycol nationallicence Solid Dispersion nationallicence Bandari Suresh Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Jadav Subash Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Eedara Basanth Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Jukanti Raju Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Veerareddy Prabhakar Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/1(2013-01-01), 238-244 0256-1115 30:1<238 2013 30 11814 https://doi.org/10.1007/s11814-012-0133-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-012-0133-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bandari Suresh Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 700 1- Jadav Subash Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 700 1- Eedara Basanth Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 700 1- Jukanti Raju Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 700 1- Veerareddy Prabhakar Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/1(2013-01-01), 238-244 0256-1115 30:1<238 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer