naa a22 4500 510819265 CHVBK 20180411083523.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11814-013-0044-5 doi (NATIONALLICENCE)springer-10.1007/s11814-013-0044-5 Selective enantioseparation of levocetirizine via a hollow fiber supported liquid membrane and mass transfer prediction [Elektronische Daten] [Niti Sunsandee, Natchanun Leepipatpiboon, Prakorn Ramakul] The enantioselective separation of levocetirizine via a hollow fiber supported liquid membrane was examined. O,O′-dibenzoyl-(2R,3R)-tartaric acid ((−)-DBTA) diluted in 1-decanol was used as a chiral selector extractant. The influence of concentrations of feed and stripping phases, and extractant concentration in the membrane phase, was also investigated. A mathematical model focusing on the extraction side of the liquid membrane system was presented to predict the concentration of levocetirizine at different times. The extraction and recovery of levocetirizine from feed phase were 75.00% and 72.00%, respectively. The mass transfer coefficients at aqueous feed boundary layer (k f ) and the organic liquid membrane phase (k m ) were calculated as 2.41×102 and 1.89×102 cm/s, respectively. The validity of the developed model was evaluated through a comparison with experimental data, and good agreement was obtained. Korean Institute of Chemical Engineers, Seoul, Korea, 2013 Levocetirizine nationallicence (−)-DBTA nationallicence Liquid Membrane nationallicence Hollow Fiber nationallicence Enantioselective Separation nationallicence Sunsandee Niti Government Pharmaceutical Organization, 10400, Ratchathevi, Bangkok, Thailand aut Leepipatpiboon Natchanun Chromatography and Separation Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, 10330, Patumwan, Bangkok, Thailand aut Ramakul Prakorn Department of Chemical Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, 73000, Nakhon Pathom, Thailand aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/6(2013-06-01), 1312-1320 0256-1115 30:6<1312 2013 30 11814 https://doi.org/10.1007/s11814-013-0044-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-013-0044-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sunsandee Niti Government Pharmaceutical Organization, 10400, Ratchathevi, Bangkok, Thailand aut NATIONALLICENCE 700 1- Leepipatpiboon Natchanun Chromatography and Separation Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, 10330, Patumwan, Bangkok, Thailand aut NATIONALLICENCE 700 1- Ramakul Prakorn Department of Chemical Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, 73000, Nakhon Pathom, Thailand aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/6(2013-06-01), 1312-1320 0256-1115 30:6<1312 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer