naa a22 4500 510819427 CHVBK 20180411083524.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11814-013-0115-7 doi (NATIONALLICENCE)springer-10.1007/s11814-013-0115-7 Co-precipitation of loperamide hydrochloride and polyethylene glycol using aerosol solvent extraction system [Elektronische Daten] [Edward Widjojokusumo, Bambang Veriansyah, Yong-Suk Youn, Youn-Woo Lee, Raymond Tjandrawinata] The co-precipitation of loperamide hydrochloride (LPM) and polyethylene glycol (PEG) using aerosol solvent extraction system (ASES) was examined. Scanning electron microscopy — energy dispersive X-ray spectroscopy (SEM-EDS) analysis showed that the co-precipitation was achieved in various LPM-PEG mass ratios with changes in its morphology. In 10-50% PEG mass ratios, angular-shaped particles were formed, whereas in 65-90% PEG mass ratios, irregular-shaped particles were formed. X-ray diffraction (XRD) analysis of the co-precipitates revealed that the LPM retained amorphous structure, while, on the other hand, the PEG retained crystalline structure. Fourier transform infrared (FT-IR) spectra indicated carbonyl function group of LPM and ether function group of PEG appeared in the co-precipitates. Results of a dissolution test showed that the co-precipitates of LPM-PEG had higher dissolution rate compared to that of the raw material and processed LPM with ASES. Taken together, the co-precipitation of LPMPEG was achieved using ASES and higher in its dissolution rate. Korean Institute of Chemical Engineers, Seoul, Korea, 2013 Loperamide Hydrochloride nationallicence Polyethylene Glycol nationallicence Co-precipitation nationallicence ASES nationallicence Widjojokusumo Edward School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, 1, Gwanak-ro, Gwanak-gu, 151-744, Seoul, Korea aut Veriansyah Bambang Nanotechnology Research Laboratory, Advance Technology Development, Dexa Laboratories of Biomolecular Sciences (DLBS), PT Dexa Medica, Kawasan Industri Jababeka 2 Cikarang, Jl. Industri Selatan V, Blok PP no. 7, 17550, Bekasi, Indonesia aut Youn Yong-Suk School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, 1, Gwanak-ro, Gwanak-gu, 151-744, Seoul, Korea aut Lee Youn-Woo School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, 1, Gwanak-ro, Gwanak-gu, 151-744, Seoul, Korea aut Tjandrawinata Raymond Nanotechnology Research Laboratory, Advance Technology Development, Dexa Laboratories of Biomolecular Sciences (DLBS), PT Dexa Medica, Kawasan Industri Jababeka 2 Cikarang, Jl. Industri Selatan V, Blok PP no. 7, 17550, Bekasi, Indonesia aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/9(2013-09-01), 1797-1803 0256-1115 30:9<1797 2013 30 11814 https://doi.org/10.1007/s11814-013-0115-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-013-0115-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Widjojokusumo Edward School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, 1, Gwanak-ro, Gwanak-gu, 151-744, Seoul, Korea aut NATIONALLICENCE 700 1- Veriansyah Bambang Nanotechnology Research Laboratory, Advance Technology Development, Dexa Laboratories of Biomolecular Sciences (DLBS), PT Dexa Medica, Kawasan Industri Jababeka 2 Cikarang, Jl. Industri Selatan V, Blok PP no. 7, 17550, Bekasi, Indonesia aut NATIONALLICENCE 700 1- Youn Yong-Suk School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, 1, Gwanak-ro, Gwanak-gu, 151-744, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Youn-Woo School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, 1, Gwanak-ro, Gwanak-gu, 151-744, Seoul, Korea aut NATIONALLICENCE 700 1- Tjandrawinata Raymond Nanotechnology Research Laboratory, Advance Technology Development, Dexa Laboratories of Biomolecular Sciences (DLBS), PT Dexa Medica, Kawasan Industri Jababeka 2 Cikarang, Jl. Industri Selatan V, Blok PP no. 7, 17550, Bekasi, Indonesia aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/9(2013-09-01), 1797-1803 0256-1115 30:9<1797 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer