naa a22 4500 510820123 CHVBK 20180411083527.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11814-012-0171-4 doi (NATIONALLICENCE)springer-10.1007/s11814-012-0171-4 Enhanced transdermal deposition and characterization of quercetin-loaded ethosomes [Elektronische Daten] [Soo Park, Hye Lee, Hae Kim, Min Park, Hyun Gu] We sought to evaluate the transdermal permeation potential of quercetin-loaded ethosomes. Quercetinloaded ethosomes were prepared and characterized with regard to particle size, loading efficiency, stability, and in vitro skin permeation. The optimized formulation of ethosomes was confirmed using 2% egg phosphatidylcholine and hydrated 20% ethanol. After quercetin was applied using this formulation, the stability of the ethosomes was determined when loaded with up to 0.04% quercetin. We observed that loading efficiency was improved with increasing concentrations of quercetin. Ethosomes loaded with 0.04% quercetin showed both the greatest loading efficiency (63.9%±6.0%) and an optimal size range (132±32 nm). Ethosomes loaded with quercetin were superior in skin permeation ability (29.5±7.0 μg/cm2) compared to either ethanolic solution or liposomes. Therefore, we concluded that quercetin-loaded ethosomes increased the skin delivery of quercetin. Our results suggest that quercetin-loaded ethosomes may enhance the effect of cosmetic materials. Korean Institute of Chemical Engineers, Seoul, Korea, 2012 Ethosomes nationallicence Quercetin nationallicence Transdermal nationallicence Skin Permeation Studies nationallicence Cosmetics nationallicence Park Soo Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut Lee Hye Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut Kim Hae Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut Park Min Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut Gu Hyun Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/3(2013-03-01), 688-692 0256-1115 30:3<688 2013 30 11814 https://doi.org/10.1007/s11814-012-0171-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-012-0171-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park Soo Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Hye Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Hae Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut NATIONALLICENCE 700 1- Park Min Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut NATIONALLICENCE 700 1- Gu Hyun Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, 139-743, Seoul, Korea aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/3(2013-03-01), 688-692 0256-1115 30:3<688 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer