naa a22 4500 51082031X CHVBK 20180411083528.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11814-012-0191-0 doi (NATIONALLICENCE)springer-10.1007/s11814-012-0191-0 Synthesis of new phosphate derivative of benzothiazole and its inhibiting effect on two series of human neuroblastoma cell growth [Elektronische Daten] [Mahshid Nezhati, Gholam Riazi, Homayon Panahi, Elham Moniri, Nasir Rajabi, Mohammad Sadughi, Natasha Zaker, Robab Ardekani, Reihaneh Kooshkestani] The sodium salt of di ((1-hydroxy-2-benzothiazolium-1-yl) ethyliden-1,1-H-bisphosphonic acid) orthophosphate was synthesized and its toxicity and viability effects screened on two different human neuroblastoma cell lines. This novel derivative of benzothiazole provides a new compound in connection with research and therapeutic application for tumor cell growth inhibition. Benzothiazole was alkylated in reaction with bromoacetic acid and then converted to its H-bisphosphonic acid derivative in presence of H3PO3/POCl3. The procedure led to formation of two molecules of corresponding H-bisphosphonic acid which attached together via a phosphate bridge. The investigated compound exhibits activities (IC50 value) ranging from 14-23 μM (corresponding to human neuroblastoma SK-BE (2) and SK-NM-C cells). Korean Institute of Chemical Engineers, Seoul, Korea, 2013 Benzothiazole nationallicence Bromoacetic Acid nationallicence Neuroblastoma nationallicence Viability nationallicence SK-BE (2) nationallicence SK-NM-C nationallicence Nezhati Mahshid Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran aut Riazi Gholam Department of Pharmacology, Tehran University, Tehran, Iran aut Panahi Homayon Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran aut Moniri Elham Department of Chemistry, Islamic Azad University, Varamin Branch (Pishva), Iran aut Rajabi Nasir Department of Chemistry, Imam Khomeini International University (IKIU), Qazvine, Iran aut Sadughi Mohammad Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran aut Zaker Natasha Department of Microbiology, Islamic Azad University, Science and Research Campus, Tehran, Iran aut Ardekani Robab Department of Biochemistry, Alzahra University, Tehran, Iran aut Kooshkestani Reihaneh Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/3(2013-03-01), 675-679 0256-1115 30:3<675 2013 30 11814 https://doi.org/10.1007/s11814-012-0191-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-012-0191-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nezhati Mahshid Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran aut NATIONALLICENCE 700 1- Riazi Gholam Department of Pharmacology, Tehran University, Tehran, Iran aut NATIONALLICENCE 700 1- Panahi Homayon Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran aut NATIONALLICENCE 700 1- Moniri Elham Department of Chemistry, Islamic Azad University, Varamin Branch (Pishva), Iran aut NATIONALLICENCE 700 1- Rajabi Nasir Department of Chemistry, Imam Khomeini International University (IKIU), Qazvine, Iran aut NATIONALLICENCE 700 1- Sadughi Mohammad Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran aut NATIONALLICENCE 700 1- Zaker Natasha Department of Microbiology, Islamic Azad University, Science and Research Campus, Tehran, Iran aut NATIONALLICENCE 700 1- Ardekani Robab Department of Biochemistry, Alzahra University, Tehran, Iran aut NATIONALLICENCE 700 1- Kooshkestani Reihaneh Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/3(2013-03-01), 675-679 0256-1115 30:3<675 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer