naa a22 4500 510820352 CHVBK 20180411083528.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11814-013-0124-6 doi (NATIONALLICENCE)springer-10.1007/s11814-013-0124-6 Optimization of temperature swing strategy for selective cooling crystallization of α -form l -glutamic acid crystals [Elektronische Daten] [Seungjong Yeom, Huichan Yun, Dae Yang] l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling. Korean Institute of Chemical Engineers, Seoul, Korea, 2013 Cooling Crystallization nationallicence Population Balance Model nationallicence Polymorphic Transformation nationallicence l -Glutamic Acid nationallicence Optimization nationallicence Yeom Seungjong Department of Chemical and Biological Engineering, Korea University, Anam-dong 5-Ga, Seongbuk-gu, 136-701, Seoul, Korea aut Yun Huichan Department of Chemical and Biological Engineering, Korea University, Anam-dong 5-Ga, Seongbuk-gu, 136-701, Seoul, Korea aut Yang Dae Department of Chemical and Biological Engineering, Korea University, Anam-dong 5-Ga, Seongbuk-gu, 136-701, Seoul, Korea aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/10(2013-10-01), 1836-1842 0256-1115 30:10<1836 2013 30 11814 https://doi.org/10.1007/s11814-013-0124-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-013-0124-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yeom Seungjong Department of Chemical and Biological Engineering, Korea University, Anam-dong 5-Ga, Seongbuk-gu, 136-701, Seoul, Korea aut NATIONALLICENCE 700 1- Yun Huichan Department of Chemical and Biological Engineering, Korea University, Anam-dong 5-Ga, Seongbuk-gu, 136-701, Seoul, Korea aut NATIONALLICENCE 700 1- Yang Dae Department of Chemical and Biological Engineering, Korea University, Anam-dong 5-Ga, Seongbuk-gu, 136-701, Seoul, Korea aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/10(2013-10-01), 1836-1842 0256-1115 30:10<1836 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer