naa a22 4500 510820395 CHVBK 20180411083528.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11814-013-0143-3 doi (NATIONALLICENCE)springer-10.1007/s11814-013-0143-3 Nucleation behavior of glutathione polymorphs in water [Elektronische Daten] [Zhi Chen, Leping Dang, Shuai Li, Hongyuan Wei] Nucleation behavior of glutathione (GSH) polymorphs in water was investigated by experimental method combined with classical nucleation theory. The solubility of α and β forms GSH in water at different temperatures, and the nucleation induction period at various supersaturations and temperatures were determined experimentally. The results show that, in a certain range of supersaturation, the nucleation of β form predominates at relatively higher temperature, while α form will be obtained at lower temperature. The nucleation kinetics parameters of α and β form were then calculated. To understand the crucial role of temperature on crystal forms, "hypothetic” nucleation parameters of β form at 283.15 K were deduced based on extrapolation method. The results show that the interfacial tension, critical free energy, critical nucleus radius and nucleus number of α form are smaller than that of β form in the same condition at 283.15 K, which implies that α form nucleates easier than β form at low temperature. This work may be useful for the control and optimization of GSH crystallization process in industry. Korean Institute of Chemical Engineers, Seoul, Korea, 2013 Glutathione nationallicence Nucleation nationallicence Induction Period nationallicence Crystallization nationallicence Classical Nucleation Theory nationallicence Chen Zhi School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, P. R. China aut Dang Leping School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, P. R. China aut Li Shuai School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, P. R. China aut Wei Hongyuan School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, P. R. China aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/10(2013-10-01), 1939-1945 0256-1115 30:10<1939 2013 30 11814 https://doi.org/10.1007/s11814-013-0143-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-013-0143-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Zhi School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, P. R. China aut NATIONALLICENCE 700 1- Dang Leping School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, P. R. China aut NATIONALLICENCE 700 1- Li Shuai School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, P. R. China aut NATIONALLICENCE 700 1- Wei Hongyuan School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, P. R. China aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/10(2013-10-01), 1939-1945 0256-1115 30:10<1939 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer