naa a22 4500 510820425 CHVBK 20180411083528.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s11814-013-0114-8 doi (NATIONALLICENCE)springer-10.1007/s11814-013-0114-8 In vitro small intestinal absorption and pH stability of tableted KIOM-C and KIOM-MA-128 [Elektronische Daten] [Hyun Cha, Jin Ma, Jin-Chul Kim] Hot water extracts, KIOM-C and KIOM-MA-128, were formulated into tablets and three kinds of absorption enhancers were included in the tablets. The mixture of starch and lactose was used as an excipient, sodium carboxymethylcellulose as a disintegrating agent, and magnesium stearate as a binder. The weight ratio of water extract/excipient/disintegrating agent/absorption enhancer/binder was 80/7/10/2/1. The tablets were completely disintegrated in an aqueous solution in 40min, and the disintegration rates were almost the same with all the tablets tested. Among the enhancers, EDTA was the most effective in enhancing the in vitro small intestine absorption of KIOM-C and KIOM-MA-128. Korean Institute of Chemical Engineers, Seoul, Korea, 2013 KIOM-C, KIOM-MA-128 nationallicence Tablet nationallicence Disintegration nationallicence Small Intestine Absorption nationallicence pH Stability nationallicence Cha Hyun Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja2-dong, Chuncheon, 200-701, Kangwon-do, Korea aut Ma Jin TKM Converging Research Division, Korea Institute of Oriental Medicine, 305-811, Daejeon, Korea aut Kim Jin-Chul Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja2-dong, Chuncheon, 200-701, Kangwon-do, Korea aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/10(2013-10-01), 1929-1933 0256-1115 30:10<1929 2013 30 11814 https://doi.org/10.1007/s11814-013-0114-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-013-0114-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cha Hyun Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja2-dong, Chuncheon, 200-701, Kangwon-do, Korea aut NATIONALLICENCE 700 1- Ma Jin TKM Converging Research Division, Korea Institute of Oriental Medicine, 305-811, Daejeon, Korea aut NATIONALLICENCE 700 1- Kim Jin-Chul Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja2-dong, Chuncheon, 200-701, Kangwon-do, Korea aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/10(2013-10-01), 1929-1933 0256-1115 30:10<1929 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer