naa a22 4500 51082059X CHVBK 20180411083529.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11814-012-0209-7 doi (NATIONALLICENCE)springer-10.1007/s11814-012-0209-7 Effects of fruiting body extracts of Lentinus edodes cultivated using corn cob on biological activities [Elektronische Daten] [Jong-Soo Kim, Dubok Choi, Bock-Gie Jung, Bong-Joo Lee, Geum-Sook Lim, Myung Lee, Wol-Suk Cha, Hoon Cho] We investigated the antioxidant, nitrite scavenging, immune-enhancing and antimicrobial effects of the Lentinus edodes fruiting body extracts (LEFB extract) cultivated in the solid state using corn cob. The CAT, SOD and GSH-Px activities in the LEFB extract (400mg)-fed group were approximately 1.70, 1.64, and 2.2 times higher than those of the control group. The nitrite scavenging activity was highest (86.4%) when the LEFB extract concentration was 600 μg/mL. The immune-enhancing and antimicrobial effects of LEFB extract after an experimental Bordetella bronchiseptica infection were examined. White blood and neutrophil in the LEFB extract (400 mg)-fed group were approximately 2.1 and 2.2 times higher, respectively, than those of the control group. The total leukocyte was 30% higher than that of the control group. The CD4: CD8 ratio in the LEFB extract (200 mg)-fed group was increased approximately 54.3% compared to that of the control group. The levels of TNF-α and IFN-γ mRNA expression in the LEFB extract (400 mg)-fed group were approximately 49 and 50% lower than those of the control group. The bacteria and inflammatory cell in the LEFB extract (400 mg)-fed group were approximately 48.7 and 29% lower, respectively, than that of the control group. These results suggest that the LEFB extract may be useful in immune function improvement. Korean Institute of Chemical Engineers, Seoul, Korea, 2012 Lentinus edodes nationallicence Corn Cob nationallicence Antioxidant Activity nationallicence Nitrite Scavenging Activity nationallicence Immune-enhancing Activity nationallicence Antimicrobial Effect nationallicence Kim Jong-Soo School of Chemical Engineering, Chonbuk National University, 561-756, Jeonju, Korea aut Choi Dubok Department of Pharmacy, College of Pharmacy, Chungbuk National University, 361-763, Cheongju, Korea aut Jung Bock-Gie College of Veterinary Medicine, Chonnam National University, 500-757, Gwangju, Korea aut Lee Bong-Joo College of Veterinary Medicine, Chonnam National University, 500-757, Gwangju, Korea aut Lim Geum-Sook Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University Graduate School, 500-757, Gwangju, Korea aut Lee Myung Department of Pharmacy, College of Pharmacy, Chungbuk National University, 361-763, Cheongju, Korea aut Cha Wol-Suk Department of Polymer Science & Engineering, Chosun University, 501-759, Gwangju, Korea aut Cho Hoon Department of Polymer Science & Engineering, Chosun University, 501-759, Gwangju, Korea aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/4(2013-04-01), 906-912 0256-1115 30:4<906 2013 30 11814 https://doi.org/10.1007/s11814-012-0209-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-012-0209-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Jong-Soo School of Chemical Engineering, Chonbuk National University, 561-756, Jeonju, Korea aut NATIONALLICENCE 700 1- Choi Dubok Department of Pharmacy, College of Pharmacy, Chungbuk National University, 361-763, Cheongju, Korea aut NATIONALLICENCE 700 1- Jung Bock-Gie College of Veterinary Medicine, Chonnam National University, 500-757, Gwangju, Korea aut NATIONALLICENCE 700 1- Lee Bong-Joo College of Veterinary Medicine, Chonnam National University, 500-757, Gwangju, Korea aut NATIONALLICENCE 700 1- Lim Geum-Sook Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University Graduate School, 500-757, Gwangju, Korea aut NATIONALLICENCE 700 1- Lee Myung Department of Pharmacy, College of Pharmacy, Chungbuk National University, 361-763, Cheongju, Korea aut NATIONALLICENCE 700 1- Cha Wol-Suk Department of Polymer Science & Engineering, Chosun University, 501-759, Gwangju, Korea aut NATIONALLICENCE 700 1- Cho Hoon Department of Polymer Science & Engineering, Chosun University, 501-759, Gwangju, Korea aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/4(2013-04-01), 906-912 0256-1115 30:4<906 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer