naa a22 4500 510820883 CHVBK 20180411083531.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11814-013-0110-z doi (NATIONALLICENCE)springer-10.1007/s11814-013-0110-z Proliposomes of lisinopril dihydrate for transdermal delivery: Formulation aspects and evaluation [Elektronische Daten] [Suresh Bandari, Swetha Gangishetty, Basanth Eedara, Raju Jukanti, Prabhakar Veerareddy] We formulated and evaluated proliposomal gel of relatively low bioavailable drug lisinopril dihydrate (LDH) for transdermal delivery. Several proliposomal gel formulations of lisinopril dihydrate were prepared by modified coacervation phase separation method and examined for formation of liposomes by optical microscope and characterized by transmission electron microscopy. The formulations were evaluated for size, zeta potential, entrapment efficiency, rheological behavior, ex vivo drug permeation, skin irritation and stability. Differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR) studies were performed to understand the phase transition behavior and mechanism for skin permeation, respectively. The microscopic examination revealed the formation of liposomes from proliposomal gel, and the size of the vesicles was found to be in the range of 385 nm to 635 nm. Entrapment efficiency was high for the formulation containing greater amounts of phosphatidylcholine. The DSC studies indicated the amorphous form of LDH in proliposomal gel formulation. Ex vivo permeation studies revealed sustained permeation of drug from proliposomal gels studied. The stability studies reveal that the proliposomal formulations are more stable when stored at refrigeration temperature (4 °C). In conclusion, proliposomal gels offer potential and prove to be efficient carriers for improved and sustained transdermal delivery of lisinopril dihydrate. Korean Institute of Chemical Engineers, Seoul, Korea, 2013 Lisinopril Dihydrate nationallicence Proliposomes nationallicence Microscopy nationallicence Transdermal nationallicence Permeability nationallicence Bandari Suresh Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Gangishetty Swetha Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Eedara Basanth Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Jukanti Raju Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Veerareddy Prabhakar Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/8(2013-08-01), 1659-1666 0256-1115 30:8<1659 2013 30 11814 https://doi.org/10.1007/s11814-013-0110-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-013-0110-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bandari Suresh Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 700 1- Gangishetty Swetha Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 700 1- Eedara Basanth Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 700 1- Jukanti Raju Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 700 1- Veerareddy Prabhakar Department of Pharmaceutics, St. Peter's Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Warangal, India aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/8(2013-08-01), 1659-1666 0256-1115 30:8<1659 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer