naa a22 4500 51082157X CHVBK 20180411083535.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s11814-012-0131-z doi (NATIONALLICENCE)springer-10.1007/s11814-012-0131-z Surface plasmon resonance study of (positive, neutral, negative) vesicles rupture by AgNPs' attack for screening of cytotoxicity induced by nanoparticles [Elektronische Daten] [Ha Umh, Younghun Kim] As the use of nanomaterials in industrial and commercial applications is growing, official reports concerning possible environmental and health effects of nanoparticles are also steadily increasing. Many toxicological studies on the adverse effects of silver nanoparticles (AgNPs) have used living organisms, which is a time consuming process. Therefore, we propose an alternative method to assess the in-vivo and in-vitro cytotoxicity of nanomaterials, involving a fast and simple screening procedure for vesicle rupture or fusion by the attack of AgNPs. With the assumption that particle interaction between AgNPs and vesicles is induced by electrostatic repulsion or attraction of surface charge, three vesicles with different charges (positive, neutral, and negative) were prepared and they were dispersed with AgNPs in different pH (3, 7, and 10) solutions to control the surface charge of AgNPs. Based on the results of vesicle rupture analyzed by SPR and TEM, screening of cell rupture through vesicles by AgNPs' attack is determined to be most suitable at pH 7. Korean Institute of Chemical Engineers, Seoul, Korea, 2012 Silver Nanoparticles nationallicence Vesicles nationallicence Nanotoxicity nationallicence Cell Rupture nationallicence SPR nationallicence Umh Ha Department of Chemical Engineering, Kwangwoon University, 139-701, Seoul, Korea aut Kim Younghun Department of Chemical Engineering, Kwangwoon University, 139-701, Seoul, Korea aut Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/2(2013-02-01), 482-487 0256-1115 30:2<482 2013 30 11814 https://doi.org/10.1007/s11814-012-0131-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11814-012-0131-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Umh Ha Department of Chemical Engineering, Kwangwoon University, 139-701, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Younghun Department of Chemical Engineering, Kwangwoon University, 139-701, Seoul, Korea aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer US; http://www.springer-ny.com 30/2(2013-02-01), 482-487 0256-1115 30:2<482 2013 30 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer