naa a22 4500 51082269X CHVBK 20180411083541.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12541-013-0163-2 doi (NATIONALLICENCE)springer-10.1007/s12541-013-0163-2 Effects of medication and deep brain stimulation on speed and amplitude are different between finger and forearm in patient with Parkinson's disease [Elektronische Daten] [Ji-Won Kim, Yuri Kwon, Yeji Ho, Sang-Hoon Park, Chul-Seung Kim, Gwang-Moon Eom, Jae-Hoon Jun, Jeong-Whan Lee, Kyeong-Seop Kim, Min-Jik Kim, Seong-Beom Koh] Although differential effects of medication and deep brain stimulation (DBS) on bradykinesia have been addressed in the literature, speed and amplitude have not been separated. This study investigated the differential effects of medication and DBS on quantitative measures of speed and amplitude, as well as on proximal and distal muscles of upper extremities. Fourteen upper limbs affected by Parkinson's disease were tested. Finger tapping and forearm rotation were performed to investigate distal and proximal bradykinesia, respectively. Test conditions included off-treatment, DBS only, medication only, and medication + DBS. Quantitative outcome measures included root-mean-square average of speed and amplitude. Two-way and one-way ANOVA (analysis of variance) were performed to investigate the effects of medication and DBS, and to compare the performance in four test conditions, respectively. Speed was improved at both body parts, whereas amplitude was improved only at the proximal forearm (p < 0.01). Medication tended to be better than DBS at distal speed, whereas DBS tended to be better than medication at proximal amplitude. Medication + DBS resulted in the best average performance in all outcome measures. Improvement in speed and amplitude in each body parts are differentially associated with medication and DBS. Medication and DBS have complementary effects in amelioration of bradykinesia. The findings may be helpful for clinical interventions and evaluations. Korean Society for Precision Engineering and Springer-Verlag Berlin Heidelberg, 2013 Bradykinesia nationallicence Deep brain stimulation nationallicence Medication nationallicence Amplitude nationallicence Speed nationallicence Kim Ji-Won School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut Kwon Yuri School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut Ho Yeji School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut Park Sang-Hoon aut Kim Chul-Seung School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut Eom Gwang-Moon School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut Jun Jae-Hoon School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut Lee Jeong-Whan School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut Kim Kyeong-Seop School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut Kim Min-Jik Department of Neurology, Korea University College of Medicine, 136-705, Seoul, Korea aut Koh Seong-Beom Department of Neurology, Korea University College of Medicine, 136-705, Seoul, Korea aut International Journal of Precision Engineering and Manufacturing Springer Berlin Heidelberg 14/7(2013-07-01), 1201-1207 2234-7593 14:7<1201 2013 14 12541 https://doi.org/10.1007/s12541-013-0163-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12541-013-0163-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Ji-Won School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut NATIONALLICENCE 700 1- Kwon Yuri School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut NATIONALLICENCE 700 1- Ho Yeji School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut NATIONALLICENCE 700 1- Park Sang-Hoon aut NATIONALLICENCE 700 1- Kim Chul-Seung School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut NATIONALLICENCE 700 1- Eom Gwang-Moon School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut NATIONALLICENCE 700 1- Jun Jae-Hoon School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut NATIONALLICENCE 700 1- Lee Jeong-Whan School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut NATIONALLICENCE 700 1- Kim Kyeong-Seop School of Biomedical Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si, 380-701, Chungbuk, Korea aut NATIONALLICENCE 700 1- Kim Min-Jik Department of Neurology, Korea University College of Medicine, 136-705, Seoul, Korea aut NATIONALLICENCE 700 1- Koh Seong-Beom Department of Neurology, Korea University College of Medicine, 136-705, Seoul, Korea aut NATIONALLICENCE 773 0- International Journal of Precision Engineering and Manufacturing Springer Berlin Heidelberg 14/7(2013-07-01), 1201-1207 2234-7593 14:7<1201 2013 14 12541 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer