naa a22 4500 510822843 CHVBK 20180411083542.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12541-013-0162-3 doi (NATIONALLICENCE)springer-10.1007/s12541-013-0162-3 Development of quantitative evaluation factors for determining the level of facial muscle relaxation in rabbits using facial muscle electromyography [Elektronische Daten] [Young Kim, Yang Cho, Ga Park, Ahnryul Choi, Su Youn, Taeyong Sim, Seung Oh, Heegoo Yang, Hyunjoon Park, Dongjune Lee, Dae-weon Lee, Joung Mun] Permanent facial nerve damage is one of the most critical complications that can occur during otologic and neurosurgical procedures. As a result, facial nerve monitoring equipment is now used in most of otologic surgeries. The monitoring devices used for this purpose usually evaluate the activity of facial muscle in response to stimulation to the facial nerve. For these purposes, electromyography and the train-of-four (TOF) method is commonly used clinically, but these approaches have an important limitation: this qualitative method only depends on visual information of finger movement. Thus, in this study, a new factor that can be used to quantitatively the stage of muscle relaxation at the facial nerve was developed based on the degree of muscle relaxation and electro-stimulation. Ketamine intravenous anesthesia and isoflurane inhalation anesthesia was given to 13 rabbits. A 28 G unipolar needle-electrode was inserted at an exposed facial nerve, and stimulated (0.1 mA-5.0 mA) with an electrical stimulator. Also, the degree of muscle relaxation based electromyographic signal acquisition was performed while increasing the dose of neuromuscular blockades. After data noise reduction and normalization, the collected EMG signals were divided into 33 variables, and a new evaluation factor was developed using statistical methods based on multiple linear regression models and principal component analysis. A new evaluation factor was identified that can be used to quantitatively estimate each phase in muscle relation. The evaluating factors that were calculated in accordance with the electrical simulation resulted in improved results (r = 0.96) when compared to the existing assessment methods. (T1 ratio r = 0.72; T4/T1 ration r = 0.52). Korean Society for Precision Engineering and Springer-Verlag Berlin Heidelberg, 2013 Depth of muscle relaxation nationallicence Electromyography nationallicence Facial nerve nationallicence Muscle relaxation nationallicence Principal component analysis nationallicence Kim Young Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut Cho Yang Dept. of Otorhinolaryngology and Head & Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon, Gangnam, 135-710, Seoul, Korea aut Park Ga Dept. of Otorhinolaryngology and Head & Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon, Gangnam, 135-710, Seoul, Korea aut Choi Ahnryul Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut Youn Su Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut Sim Taeyong Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut Oh Seung Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut Yang Heegoo Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut Park Hyunjoon Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut Lee Dongjune Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut Lee Dae-weon Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut Mun Joung Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut International Journal of Precision Engineering and Manufacturing Springer Berlin Heidelberg 14/7(2013-07-01), 1193-1199 2234-7593 14:7<1193 2013 14 12541 https://doi.org/10.1007/s12541-013-0162-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12541-013-0162-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Young Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 700 1- Cho Yang Dept. of Otorhinolaryngology and Head & Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon, Gangnam, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Park Ga Dept. of Otorhinolaryngology and Head & Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon, Gangnam, 135-710, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Ahnryul Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 700 1- Youn Su Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 700 1- Sim Taeyong Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 700 1- Oh Seung Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 700 1- Yang Heegoo Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 700 1- Park Hyunjoon Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 700 1- Lee Dongjune Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 700 1- Lee Dae-weon Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 700 1- Mun Joung Dept. of Bio-Mechatronic Engineering, College of Biotechnology & Bioengineering, Sungkyunkwan University, 300 Chunchun, Jangan, Suwon, 440-746, Gyeonggi, Korea aut NATIONALLICENCE 773 0- International Journal of Precision Engineering and Manufacturing Springer Berlin Heidelberg 14/7(2013-07-01), 1193-1199 2234-7593 14:7<1193 2013 14 12541 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer