naa a22 4500 510822924 CHVBK 20180411083542.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12541-013-0298-1 doi (NATIONALLICENCE)springer-10.1007/s12541-013-0298-1 3D scaffold with PCL combined biomedical ceramic materials for bone tissue regeneration [Elektronische Daten] [Ming-Jyh Chern, Liang-Yo Yang, Yung-Kang Shen, Jia-Hsiang Hung] Three-dimensional porous biodegradable polymer scaffolds have been widely used for tissue engineering of bone repair or regeneration. The primary function of scaffolds is to provide structure support for the cells adhesion and proliferation. This study selects the Poly-ɛ-caprolactone (PCL) as material, NaCl mixed with hydroxyapatite (HA) or nano-aluminum oxide (nAl2O3) for porous scaffold. This study uses the solvent casting/particulate leaching method to fabricate the porous scaffold. The authors discuss the compression mechanical properties, physical properties (porosity, moisture content, contact angle) of a pure PCL, PCL/mHA, PCL/nHA and PCL/nAl2O3 scaffolds. In vitro cell culture is used for osteoblast cell (MG63) and the microculture tetrazolium test (MTT) is undertaken in the scaffold. The scaffolds are implanted to the femur of rats and histological examination is attempted after 2 weeks. The experimental results indicate that HA and nAl2O3 can improve the hydrophilic property. In conclusion, the PCL/nHA scaffold exhibits splendid in vivo biocompatibility and osteogenesis. Korean Society for Precision Engineering and Springer-Verlag Berlin Heidelberg, 2013 Mechanical properties nationallicence Porosity/Voids nationallicence Scanning electron microscopy (SEM) nationallicence In vitro/In vivo nationallicence Chern Ming-Jyh Department of Mechanical Engineering, National Taiwan University of Science and Technology, 106, Taipei, Taiwan, R.O.C. aut Yang Liang-Yo Department of Physiology, School of Medicine, College of Medicine, Taipei Medicine University, 11031, Taipei, Taiwan, R.O.C aut Shen Yung-Kang School of Dental Technology, College of Oral Medicine, Taipei Medical University, 11031, Taipei, Taiwan, R.O.C aut Hung Jia-Hsiang Department of Mechanical Engineering, National Taiwan University of Science and Technology, 106, Taipei, Taiwan, R.O.C. aut International Journal of Precision Engineering and Manufacturing Springer Berlin Heidelberg 14/12(2013-12-01), 2201-2207 2234-7593 14:12<2201 2013 14 12541 https://doi.org/10.1007/s12541-013-0298-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12541-013-0298-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chern Ming-Jyh Department of Mechanical Engineering, National Taiwan University of Science and Technology, 106, Taipei, Taiwan, R.O.C aut NATIONALLICENCE 700 1- Yang Liang-Yo Department of Physiology, School of Medicine, College of Medicine, Taipei Medicine University, 11031, Taipei, Taiwan, R.O.C aut NATIONALLICENCE 700 1- Shen Yung-Kang School of Dental Technology, College of Oral Medicine, Taipei Medical University, 11031, Taipei, Taiwan, R.O.C aut NATIONALLICENCE 700 1- Hung Jia-Hsiang Department of Mechanical Engineering, National Taiwan University of Science and Technology, 106, Taipei, Taiwan, R.O.C aut NATIONALLICENCE 773 0- International Journal of Precision Engineering and Manufacturing Springer Berlin Heidelberg 14/12(2013-12-01), 2201-2207 2234-7593 14:12<2201 2013 14 12541 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer