naa a22 4500 52874464X 20180922060414.0 cr unu---uuuuu 180922s2018 xx s 000 0 eng 2211-3207 10.1016/j.ijpddr.2018.07.001 doi (EDOC)oai:edoc.unibas.ch:65029 30007544 pmid Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota [Elektronische Daten] [Pierre H. H. Schneeberger, Jean T. Coulibaly, Morgan Gueuning, Wendelin Moser, Bryan Coburn, Jürg E. Frey, Jennifer Keiser] Soil-transmitted helminths infect 1.5 billion people worldwide. Treatment with anthelminthics is the key intervention but interactions between anthelminthic agents and the gut microbiota have not yet been studied. In this study, the effects of four anthelminthic drugs and combinations (tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate) on the gut microbiota were assessed. From each hookworm infected adolescent, one stool sample was collected prior to treatment, 24 h post-treatment and 3 weeks post-treatment, and a total of 144 stool samples were analyzed. The gut bacterial composition was analyzed using 16S rRNA gene sequencing. Tribendimidine given alone or together with oxantel-pamoate, and the combination of albendazole and oxantel pamoate were not associated with any major changes in the taxonomic composition of the gut microbiota in this population, at both the short-term post-treatment (24 h) and long-term post-treatment (3 weeks) periods. A high abundance of the bacterial phylum Bacteroidetes was observed following administration of tribendimidine plus ivermectin 24 h after treatment, due predominantly to difference in abundance of the families Prevotellaceae and Candidatus homeothermaceae. This effect is transient and disappears three weeks after treatment. Higher abundance of Bacteroidetes predicts an increase in metabolic pathways involved in the synthesis of B vitamins. This study highlights a strong relationship between tribendimidine and ivermectin administration and the gut microbiota and additional studies assessing the functional aspects as well as potential health-associated outcomes of these interactions are required. Schneeberger Pierre H. H. joint author Coulibaly Jean T. joint author Gueuning Morgan joint author Moser Wendelin joint author Coburn Bryan joint author Frey Jürg E. joint author Keiser Jennifer joint author International journal for parasitology. Drugs and drug resistance 8 (3), pp. 372-378 2211-3207 https://edoc.unibas.ch/65029/1/20180725115756_5b5849a4e3f46.pdf text/html WWW-Backlink auf das Repository 1 Article edoc PeerReviewed edoc peerstatus EDOC 856 40 https://edoc.unibas.ch/65029/1/20180725115756_5b5849a4e3f46.pdf text/html WWW-Backlink auf das Repository EDOC 700 1- Schneeberger Pierre H. H. joint author EDOC 700 1- Coulibaly Jean T. joint author EDOC 700 1- Gueuning Morgan joint author EDOC 700 1- Moser Wendelin joint author EDOC 700 1- Coburn Bryan joint author EDOC 700 1- Frey Jürg E. joint author EDOC 700 1- Keiser Jennifer joint author EDOC 773 0- International journal for parasitology. Drugs and drug resistance 8 (3), pp. 372-378 2211-3207 BK010053 XK010053 XK010000 EDOC EDOC EDOC Article