naa a22 4500 528782517 20180924065513.0 cr unu---uuuuu 180924e20130624xx s 000 0 eng 10.3929/ethz-b-000070752 doi 10.1371/journal.pone.0067344 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/70752 Is Motor Learning Mediated by tDCS Intensity? [Elektronische Daten] [Koen Cuypers, Daphnie J.F. Leenus, Femke E. van den Berg, Michael A. Nitsche, Herbert Thijs, Nicole Wenderoth, Raf L.J. Meesen] PLoS ONE Open access ethresearch Although tDCS has been shown to improve motor learning, previous studies reported rather small effects. Since physiological effects of tDCS depend on intensity, the present study evaluated this parameter in order to enhance the effect of tDCS on skill acquisition. The effect of different stimulation intensities of anodal tDCS (atDCS) was investigated in a double blind, sham controlled crossover design. In each condition, thirteen healthy subjects were instructed to perform a unimanual motor (sequence) learning task. Our results showed (1) a significant increase in the slope of the learning curve and (2) a significant improvement in motor performance at retention for 1.5 mA atDCS as compared to sham tDCS. No significant differences were reported between 1 mA atDCS and sham tDCS; and between 1.5 mA atDCS and 1 mA atDCS. Creative Commons Attribution 3.0 Unported http://creativecommons.org/licenses/by/3.0 ethresearch Cuypers Koen joint author Leenus Daphnie J.F. joint author van den Berg Femke E. joint author Nitsche Michael A. joint author Thijs Herbert joint author Wenderoth Nicole joint author Meesen Raf L.J. joint author PLoS ONE San Francisco, CA, USA : Public Library of Science 8 (6), p. e67344 1932-6203 http://hdl.handle.net/20.500.11850/70752 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/70752 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Cuypers Koen joint author ETHRESEARCH 700 1- Leenus Daphnie J.F. joint author ETHRESEARCH 700 1- van den Berg Femke E. joint author ETHRESEARCH 700 1- Nitsche Michael A. joint author ETHRESEARCH 700 1- Thijs Herbert joint author ETHRESEARCH 700 1- Wenderoth Nicole joint author ETHRESEARCH 700 1- Meesen Raf L.J. joint author ETHRESEARCH 773 0- PLoS ONE San Francisco, CA, USA : Public Library of Science 8 (6), p. e67344 1932-6203 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access