A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone)
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| 005 | 20190819030723.0 | ||
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| 008 | 180924e201808 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000280003 |2 doi |
| 024 | 7 | 0 | |a 10.3390/polym10080851 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/280003 | ||
| 245 | 0 | 2 | |a A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone) |h [Elektronische Daten] |c [Alberto Cingolani, Tommaso Casalini, Stefano Caimi, Antoine Klaue, Mattia Sponchioni, Filippo Rossi, Giuseppe Perale] |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a In the last decades bioresorbable and biodegradable polymers have gained a very good reputation both in research and in industry thanks to their unique characteristics. They are able to ensure high performance and biocompatibility, at the same time avoiding post-healing surgical interventions for device removal. In the medical device industry, it is widely known that product formulation and manufacturing need to follow specific procedures in order to ensure both the proper mechanical properties and desired degradation profile. Moreover, the sterilization method is crucial and its impact on physical properties is generally underestimated. In this work we focused our attention on the effect of different terminal sterilization methods on two commercially available poly(l-lactide-co-ε-caprolactone) with equivalent chemical composition (70% PLA and 30% PCL) and relatively similar initial molecular weights, but different chain arrangements and crystallinity. Results obtained show that crystallinity plays a key role in helping preserve the narrow distribution of chains and, as a consequence, defined physical properties. These statements can be used as guidelines for a better choice of the most adequate biodegradable polymers in the production of resorbable medical devices. | |
| 540 | |a Creative Commons Attribution 4.0 International |u http://creativecommons.org/licenses/by/4.0 |2 ethresearch | ||
| 690 | 7 | |a electron beam |2 ethresearch | |
| 690 | 7 | |a ethylene oxide |2 ethresearch | |
| 690 | 7 | |a medical devices |2 ethresearch | |
| 690 | 7 | |a polymers |2 ethresearch | |
| 690 | 7 | |a sterilization |2 ethresearch | |
| 700 | 1 | |a Cingolani |D Alberto |e joint author | |
| 700 | 1 | |a Casalini |D Tommaso |e joint author | |
| 700 | 1 | |a Caimi |D Stefano |e joint author | |
| 700 | 1 | |a Klaue |D Antoine |e joint author | |
| 700 | 1 | |a Sponchioni |D Mattia |e joint author | |
| 700 | 1 | |a Rossi |D Filippo |e joint author | |
| 700 | 1 | |a Perale |D Giuseppe |e joint author | |
| 773 | 0 | |t Polymers |d Basel : MDPI |g 10 (8), p. 851 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/280003 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/280003 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Cingolani |D Alberto |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Casalini |D Tommaso |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Caimi |D Stefano |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Klaue |D Antoine |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Sponchioni |D Mattia |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Rossi |D Filippo |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Perale |D Giuseppe |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t Polymers |d Basel : MDPI |g 10 (8), p. 851 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||