caa a22 4500 528783270 20190819030723.0 cr unu---uuuuu 180924e201808 xx s 000 0 eng 10.3929/ethz-b-000280003 doi 10.3390/polym10080851 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/280003 A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone) [Elektronische Daten] [Alberto Cingolani, Tommaso Casalini, Stefano Caimi, Antoine Klaue, Mattia Sponchioni, Filippo Rossi, Giuseppe Perale] Open access ethresearch In the last decades bioresorbable and biodegradable polymers have gained a very good reputation both in research and in industry thanks to their unique characteristics. They are able to ensure high performance and biocompatibility, at the same time avoiding post-healing surgical interventions for device removal. In the medical device industry, it is widely known that product formulation and manufacturing need to follow specific procedures in order to ensure both the proper mechanical properties and desired degradation profile. Moreover, the sterilization method is crucial and its impact on physical properties is generally underestimated. In this work we focused our attention on the effect of different terminal sterilization methods on two commercially available poly(l-lactide-co-ε-caprolactone) with equivalent chemical composition (70% PLA and 30% PCL) and relatively similar initial molecular weights, but different chain arrangements and crystallinity. Results obtained show that crystallinity plays a key role in helping preserve the narrow distribution of chains and, as a consequence, defined physical properties. These statements can be used as guidelines for a better choice of the most adequate biodegradable polymers in the production of resorbable medical devices. Creative Commons Attribution 4.0 International http://creativecommons.org/licenses/by/4.0 ethresearch electron beam ethresearch ethylene oxide ethresearch medical devices ethresearch polymers ethresearch sterilization ethresearch Cingolani Alberto joint author Casalini Tommaso joint author Caimi Stefano joint author Klaue Antoine joint author Sponchioni Mattia joint author Rossi Filippo joint author Perale Giuseppe joint author Polymers Basel : MDPI 10 (8), p. 851 http://hdl.handle.net/20.500.11850/280003 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/280003 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Cingolani Alberto joint author ETHRESEARCH 700 1- Casalini Tommaso joint author ETHRESEARCH 700 1- Caimi Stefano joint author ETHRESEARCH 700 1- Klaue Antoine joint author ETHRESEARCH 700 1- Sponchioni Mattia joint author ETHRESEARCH 700 1- Rossi Filippo joint author ETHRESEARCH 700 1- Perale Giuseppe joint author ETHRESEARCH 773 0- Polymers Basel : MDPI 10 (8), p. 851 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access