caa a22 4500 528783440 20181224030230.0 cr unu---uuuuu 180924e20131202xx s 000 0 eng 10.3929/ethz-b-000076850 doi 10.1371/journal.pone.0081621 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/76850 Meteorological Influences on the Incidence of Aneurysmal Subarachnoid Hemorrhage - A Single Center Study of 511 Patients [Elektronische Daten] [Marian Christoph Neidert, Michael Sprenger, Heini; id_orcid 0000-0001-9674-4837 Wernli, Jan-Karl Burkhardt, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Christoph Michael Woernle] PLoS ONE Open access ethresearch Objective To assess the potential meteorological influence on the incidence of aneurysmal subarachnoid hemorrhage (SAH). Previous studies used inhomogeneous patient groups, insufficient study periods or inappropriate statistics. Patients and Methods We analyzed 511 SAH admissions between 2004 and 2012 for which aneurysmal rupture occurred within the Zurich region. The hourly meteorological parameters considered are: surface pressure, 2-m temperature, relative humidity and wind gusts, sunshine, and precipitation. For all parameters we investigate three complementary statistical measures: i) the time evolution from 5 days before to 5 days after the SAH occurrence; ii) the deviation from the 10-year monthly mean; and iii) the change relative to the parameter's value two days before SAH occurrence. The statistical significance of the results is determined using a Monte Carlo simulation combined with a re-sampling technique (1000×). Results Regarding the meteorological parameters considered, no statistically significant signal could be found. The distributions of deviations relative to the climatology and of the changes during the two days prior to SAH events agree with the distributions for the randomly chosen days. The analysis was repeated separately for winter and summer to exclude compensating effects between the seasons. Conclusion By using high-quality meteorological data analyzed with a sophisticated and robust statistical method no clearly identifiable meteorological influence for the SAH events considered can be found. Further studies on the influence of the investigated parameters on SAH incidence seem redundant. Creative Commons Attribution 3.0 Unported http://creativecommons.org/licenses/by/3.0 ethresearch Neidert Marian Christoph joint author Sprenger Michael joint author Wernli Heini; id_orcid 0000-0001-9674-4837 joint author Burkhardt Jan-Karl joint author Krayenbühl Niklaus joint author Bozinov Oliver joint author Regli Luca joint author Woernle Christoph Michael joint author PLoS ONE S.l. : Public Library of Science 8 (12), p. e81621 1932-6203 http://hdl.handle.net/20.500.11850/76850 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/76850 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Neidert Marian Christoph joint author ETHRESEARCH 700 1- Sprenger Michael joint author ETHRESEARCH 700 1- Wernli Heini; id_orcid 0000-0001-9674-4837 joint author ETHRESEARCH 700 1- Burkhardt Jan-Karl joint author ETHRESEARCH 700 1- Krayenbühl Niklaus joint author ETHRESEARCH 700 1- Bozinov Oliver joint author ETHRESEARCH 700 1- Regli Luca joint author ETHRESEARCH 700 1- Woernle Christoph Michael joint author ETHRESEARCH 773 0- PLoS ONE S.l. : Public Library of Science 8 (12), p. e81621 1932-6203 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access