naa a22 4500 528783564 20180924065515.0 cr unu---uuuuu 180924e20110218xx s 000 0 eng 10.3929/ethz-b-000030521 doi 10.1371/journal.pone.0016052 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/30521 The Role of Recombination for the Coevolutionary Dynamics of HIV and the Immune Response [Elektronische Daten] [Rafal Mostowy, Roger D. Kouyos, David Fouchet, Sebastian; id_orcid 0000-0001-8052-3925 Bonhoeffer] PLoS ONE Open access ethresearch The evolutionary implications of recombination in HIV remain not fully understood. A plausible effect could be an enhancement of immune escape from cytotoxic T lymphocytes (CTLs). In order to test this hypothesis, we constructed a population dynamic model of immune escape in HIV and examined the viral-immune dynamics with and without recombination. Our model shows that recombination (i) increases the genetic diversity of the viral population, (ii) accelerates the emergence of escape mutations with and without compensatory mutations, and (iii) accelerates the acquisition of immune escape mutations in the early stage of viral infection. We see a particularly strong impact of recombination in systems with broad, non-immunodominant CTL responses. Overall, our study argues for the importance of recombination in HIV in allowing the virus to adapt to changing selective pressures as imposed by the immune system and shows that the effect of recombination depends on the immunodominance pattern of effector T cell responses. Creative Commons Attribution 3.0 Unported http://creativecommons.org/licenses/by/3.0 ethresearch Mostowy Rafal joint author Kouyos Roger D. joint author Fouchet David joint author Bonhoeffer Sebastian; id_orcid 0000-0001-8052-3925 joint author PLoS ONE Lawrence, KS : Public Library of Science 6 (2), p. e16052 1932-6203 http://hdl.handle.net/20.500.11850/30521 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/30521 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Mostowy Rafal joint author ETHRESEARCH 700 1- Kouyos Roger D. joint author ETHRESEARCH 700 1- Fouchet David joint author ETHRESEARCH 700 1- Bonhoeffer Sebastian; id_orcid 0000-0001-8052-3925 joint author ETHRESEARCH 773 0- PLoS ONE Lawrence, KS : Public Library of Science 6 (2), p. e16052 1932-6203 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access