Prediction of human population responses to toxic compounds by a collaborative competition
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 528784218 | ||
| 005 | 20190918042302.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924e201509 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000109369 |2 doi |
| 024 | 7 | 0 | |a 10.1038/nbt.3299 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/109369 | ||
| 245 | 0 | 0 | |a Prediction of human population responses to toxic compounds by a collaborative competition |h [Elektronische Daten] |c [Federica Eduati, Lara M. Mangravite, Tao Wang, Hao Tang, J.C. Bare, Ruili Huang, Thea Norman, Mike Kellen, Michael P. Menden, Jichen Yang, Xiaowei Zhan, Rui Zhong, Guanghua Xiao, Menghang Xia, Nour Abdo, Oksana Kosyk, The NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration, Stephen Friend, Allen Dearry, Anton Simeonov, Raymond R. Tice, Ivan Rusyn, Fred A. Wright, Gustavo Stolovitzky, Yang Xie, Julio Saez-Rodriguez] |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a The ability to computationally predict the effects of toxic compounds on humans could help address the deficiencies of current chemical safety testing. Here, we report the results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations. We measured the cytotoxicity of 156 compounds in 884 lymphoblastoid cell lines for which genotype and transcriptional data are available as part of the Tox21 1000 Genomes Project. The challenge participants developed algorithms to predict interindividual variability of toxic response from genomic profiles and population-level cytotoxicity data from structural attributes of the compounds. 179 submitted predictions were evaluated against an experimental data set to which participants were blinded. Individual cytotoxicity predictions were better than random, with modest correlations (Pearson's r < 0.28), consistent with complex trait genomic prediction. In contrast, predictions of population-level response to different compounds were higher (r < 0.66). The results highlight the possibility of predicting health risks associated with unknown compounds, although risk estimation accuracy remains suboptimal. | |
| 540 | |a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International |u http://creativecommons.org/licenses/by-nc-sa/4.0 |2 ethresearch | ||
| 690 | 7 | |a Health occupations |2 ethresearch | |
| 690 | 7 | |a High-throughput screening |2 ethresearch | |
| 690 | 7 | |a Predictive medicine |2 ethresearch | |
| 690 | 7 | |a Risk factors |2 ethresearch | |
| 700 | 1 | |a Eduati |D Federica |e joint author | |
| 700 | 1 | |a Mangravite |D Lara M. |e joint author | |
| 700 | 1 | |a Wang |D Tao |e joint author | |
| 700 | 1 | |a Tang |D Hao |e joint author | |
| 700 | 1 | |a Bare |D J.C. |e joint author | |
| 700 | 1 | |a Huang |D Ruili |e joint author | |
| 700 | 1 | |a Norman |D Thea |e joint author | |
| 700 | 1 | |a Kellen |D Mike |e joint author | |
| 700 | 1 | |a Menden |D Michael P. |e joint author | |
| 700 | 1 | |a Yang |D Jichen |e joint author | |
| 700 | 1 | |a Zhan |D Xiaowei |e joint author | |
| 700 | 1 | |a Zhong |D Rui |e joint author | |
| 700 | 1 | |a Xiao |D Guanghua |e joint author | |
| 700 | 1 | |a Xia |D Menghang |e joint author | |
| 700 | 1 | |a Abdo |D Nour |e joint author | |
| 700 | 1 | |a Kosyk |D Oksana |e joint author | |
| 700 | 0 | |a The NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration |e joint author | |
| 700 | 1 | |a Friend |D Stephen |e joint author | |
| 700 | 1 | |a Dearry |D Allen |e joint author | |
| 700 | 1 | |a Simeonov |D Anton |e joint author | |
| 700 | 1 | |a Tice |D Raymond R. |e joint author | |
| 700 | 1 | |a Rusyn |D Ivan |e joint author | |
| 700 | 1 | |a Wright |D Fred A. |e joint author | |
| 700 | 1 | |a Stolovitzky |D Gustavo |e joint author | |
| 700 | 1 | |a Xie |D Yang |e joint author | |
| 700 | 1 | |a Saez-Rodriguez |D Julio |e joint author | |
| 773 | 0 | |t Nature Biotechnology |d New York, NY : Nature Publishing Group |g 33 (9), pp. 933-940 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/109369 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/109369 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Eduati |D Federica |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Mangravite |D Lara M. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Wang |D Tao |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Tang |D Hao |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Bare |D J.C. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Huang |D Ruili |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Norman |D Thea |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Kellen |D Mike |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Menden |D Michael P. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Yang |D Jichen |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Zhan |D Xiaowei |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Zhong |D Rui |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Xiao |D Guanghua |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Xia |D Menghang |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Abdo |D Nour |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Kosyk |D Oksana |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E -- |a The NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Friend |D Stephen |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Dearry |D Allen |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Simeonov |D Anton |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Tice |D Raymond R. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Rusyn |D Ivan |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Wright |D Fred A. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Stolovitzky |D Gustavo |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Xie |D Yang |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Saez-Rodriguez |D Julio |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t Nature Biotechnology |d New York, NY : Nature Publishing Group |g 33 (9), pp. 933-940 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||