P45 Forms a Complex with FADD and Promotes Neuronal Cell Survival Following Spinal Cord Injury
| LEADER | naa a22 4500 | ||
|---|---|---|---|
| 001 | 528784447 | ||
| 005 | 20180924065517.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924e20130723xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000073961 |2 doi |
| 024 | 7 | 0 | |a 10.1371/journal.pone.0069286 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/73961 | ||
| 245 | 0 | 0 | |a P45 Forms a Complex with FADD and Promotes Neuronal Cell Survival Following Spinal Cord Injury |h [Elektronische Daten] |c [Tsung-Chang Sung, Zhijiang Chen Chen, Sandrine Thuret, Marçal Vilar, Fred H. Gage, Roland Riek, Kuo-Fen Lee] |
| 246 | 0 | |a PLoS ONE | |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a Fas-associated death domain (DD) adaptor (FADD), a member of the DD superfamily, contains both a DD and a death effector domain (DED) that are important in mediating FAS ligand-induced apoptotic signaling. P45 is a unique member of the DD superfamily in that it has a domain with sequence and structural characteristics of both DD and DED. We show that p45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling. The DED of FADD is required for the complex formation with p45. Following spinal cord injury, transgenic mice over-expressing p45 exhibit increased neuronal survival, decreased retraction of corticospinal tract fibers and improved functional recovery. Understanding p45-mediated cellular and molecular mechanisms may provide insights into facilitating nerve regeneration in humans. | |
| 540 | |a Creative Commons Attribution 3.0 Unported |u http://creativecommons.org/licenses/by/3.0 |2 ethresearch | ||
| 700 | 1 | |a Sung |D Tsung-Chang |e joint author | |
| 700 | 1 | |a Chen |D Zhijiang Chen |e joint author | |
| 700 | 1 | |a Thuret |D Sandrine |e joint author | |
| 700 | 1 | |a Vilar |D Marçal |e joint author | |
| 700 | 1 | |a Gage |D Fred H. |e joint author | |
| 700 | 1 | |a Riek |D Roland |e joint author | |
| 700 | 1 | |a Lee |D Kuo-Fen |e joint author | |
| 773 | 0 | |t PLoS ONE |d San Francisco, CA, USA : Public Library of Science |g 8 (7), p. e69286 |x 1932-6203 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/73961 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/73961 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Sung |D Tsung-Chang |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Chen |D Zhijiang Chen |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Thuret |D Sandrine |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Vilar |D Marçal |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Gage |D Fred H. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Riek |D Roland |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Lee |D Kuo-Fen |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t PLoS ONE |d San Francisco, CA, USA : Public Library of Science |g 8 (7), p. e69286 |x 1932-6203 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||