naa a22 4500 528784447 20180924065517.0 cr unu---uuuuu 180924e20130723xx s 000 0 eng 10.3929/ethz-b-000073961 doi 10.1371/journal.pone.0069286 doi (ETHRESEARCH)oai:www.research-collection.ethz.ch:20.500.11850/73961 P45 Forms a Complex with FADD and Promotes Neuronal Cell Survival Following Spinal Cord Injury [Elektronische Daten] [Tsung-Chang Sung, Zhijiang Chen Chen, Sandrine Thuret, Marçal Vilar, Fred H. Gage, Roland Riek, Kuo-Fen Lee] PLoS ONE Open access ethresearch Fas-associated death domain (DD) adaptor (FADD), a member of the DD superfamily, contains both a DD and a death effector domain (DED) that are important in mediating FAS ligand-induced apoptotic signaling. P45 is a unique member of the DD superfamily in that it has a domain with sequence and structural characteristics of both DD and DED. We show that p45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling. The DED of FADD is required for the complex formation with p45. Following spinal cord injury, transgenic mice over-expressing p45 exhibit increased neuronal survival, decreased retraction of corticospinal tract fibers and improved functional recovery. Understanding p45-mediated cellular and molecular mechanisms may provide insights into facilitating nerve regeneration in humans. Creative Commons Attribution 3.0 Unported http://creativecommons.org/licenses/by/3.0 ethresearch Sung Tsung-Chang joint author Chen Zhijiang Chen joint author Thuret Sandrine joint author Vilar Marçal joint author Gage Fred H. joint author Riek Roland joint author Lee Kuo-Fen joint author PLoS ONE San Francisco, CA, USA : Public Library of Science 8 (7), p. e69286 1932-6203 http://hdl.handle.net/20.500.11850/73961 text/html WWW-Backlink auf das Repository (Open access) 1 Journal Article ethresearch ETHRESEARCH 856 40 http://hdl.handle.net/20.500.11850/73961 text/html WWW-Backlink auf das Repository (Open access) ETHRESEARCH 700 1- Sung Tsung-Chang joint author ETHRESEARCH 700 1- Chen Zhijiang Chen joint author ETHRESEARCH 700 1- Thuret Sandrine joint author ETHRESEARCH 700 1- Vilar Marçal joint author ETHRESEARCH 700 1- Gage Fred H. joint author ETHRESEARCH 700 1- Riek Roland joint author ETHRESEARCH 700 1- Lee Kuo-Fen joint author ETHRESEARCH 773 0- PLoS ONE San Francisco, CA, USA : Public Library of Science 8 (7), p. e69286 1932-6203 BK010053 XK010053 XK010000 ETHRESEARCH ETHRESEARCH ETHRESEARCH Journal Article Open access