Salmonella-Induced Mucosal Lectin RegIIIβ Kills Competing Gut Microbiota
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 528784935 | ||
| 005 | 20190923032428.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924e20110609xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000037487 |2 doi |
| 024 | 7 | 0 | |a 10.1371/journal.pone.0020749 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/37487 | ||
| 245 | 0 | 0 | |a Salmonella-Induced Mucosal Lectin RegIIIβ Kills Competing Gut Microbiota |h [Elektronische Daten] |c [Christian Stelter, Rina Käppeli, Claudia König, Alexander Krah, Wolf-Dietrich; id_orcid 0000-0002-9892-6420 Hardt, Bärbel Stecher, Dirk Bumann] |
| 246 | 0 | |a PLoS ONE | |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a Intestinal inflammation induces alterations of the gut microbiota and promotes overgrowth of the enteric pathogen Salmonella enterica by largely unknown mechanisms. Here, we identified a host factor involved in this process. Specifically, the C-type lectin RegIIIβ is strongly upregulated during mucosal infection and released into the gut lumen. In vitro, RegIIIβ kills diverse commensal gut bacteria but not Salmonella enterica subspecies I serovar Typhimurium (S. Typhimurium). Protection of the pathogen was attributable to its specific cell envelope structure. Co-infection experiments with an avirulent S. Typhimurium mutant and a RegIIIβ-sensitive commensal E. coli strain demonstrated that feeding of RegIIIβ was sufficient for suppressing commensals in the absence of all other changes inflicted by mucosal disease. These data suggest that RegIIIβ production by the host can promote S. Typhimurium infection by eliminating inhibitory gut microbiota. | |
| 540 | |a Creative Commons Attribution 3.0 Unported |u http://creativecommons.org/licenses/by/3.0 |2 ethresearch | ||
| 700 | 1 | |a Stelter |D Christian |e joint author | |
| 700 | 1 | |a Käppeli |D Rina |e joint author | |
| 700 | 1 | |a König |D Claudia |e joint author | |
| 700 | 1 | |a Krah |D Alexander |e joint author | |
| 700 | 1 | |a Hardt |D Wolf-Dietrich; id_orcid 0000-0002-9892-6420 |e joint author | |
| 700 | 1 | |a Stecher |D Bärbel |e joint author | |
| 700 | 1 | |a Bumann |D Dirk |e joint author | |
| 773 | 0 | |t PLoS ONE |d Lawrence, KS, USA : Public Library of Science |g 6 (6), p. e20749 |x 1932-6203 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/37487 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/37487 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Stelter |D Christian |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Käppeli |D Rina |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a König |D Claudia |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Krah |D Alexander |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Hardt |D Wolf-Dietrich; id_orcid 0000-0002-9892-6420 |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Stecher |D Bärbel |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Bumann |D Dirk |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t PLoS ONE |d Lawrence, KS, USA : Public Library of Science |g 6 (6), p. e20749 |x 1932-6203 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||